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rdf:type |
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lifeskim:mentions |
umls-concept:C0051733,
umls-concept:C0220781,
umls-concept:C0243071,
umls-concept:C0332256,
umls-concept:C0441655,
umls-concept:C0600115,
umls-concept:C0772162,
umls-concept:C0871161,
umls-concept:C1148673,
umls-concept:C1433453,
umls-concept:C1883254
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pubmed:issue |
6
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pubmed:dateCreated |
2004-3-4
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|
pubmed:abstractText |
Amonafide- and elinafide-related mono and bisintercalators, modified by the introduction of a pi-excedent furan or thiophene ring fused to the naphthalimide moiety, have been synthesized. These compounds have shown an interesting antitumor profile. The best compound, 9, was 2.5-fold more potent than elinafide against human colon carcinoma cells (HT-29). Molecular dynamic simulations and physicochemical experiments have demonstrated that these compounds are capable of forming stable DNA complexes. These results, together with those previously reported by us for imidazo- and pyrazinonaphthalimide analogues, have prompted us to propose that the DNA binding process does not depend on the electronic nature of the fused heterocycle.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:AbradeloCristinaC,
pubmed-author:Báñez-CoronelMónicaM,
pubmed-author:BrañaMiguel FMF,
pubmed-author:CachoMónicaM,
pubmed-author:DomínguezM TeresaMT,
pubmed-author:GarcíaMario AMA,
pubmed-author:LacalJuan CarlosJC,
pubmed-author:PozueloJosé MJM,
pubmed-author:RamosAnaA,
pubmed-author:Rey-StolleMaría FernandaMF,
pubmed-author:YusteMercedesM,
pubmed-author:de Pascual-TeresaBeatrizB
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pubmed:issnType |
Print
|
|
pubmed:day |
11
|
|
pubmed:volume |
47
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1391-9
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14998328-Amides,
pubmed-meshheading:14998328-Animals,
pubmed-meshheading:14998328-Cell Line, Tumor,
pubmed-meshheading:14998328-DNA,
pubmed-meshheading:14998328-Drug Screening Assays, Antitumor,
pubmed-meshheading:14998328-Furans,
pubmed-meshheading:14998328-Humans,
pubmed-meshheading:14998328-Imides,
pubmed-meshheading:14998328-Intercalating Agents,
pubmed-meshheading:14998328-Isoquinolines,
pubmed-meshheading:14998328-Mice,
pubmed-meshheading:14998328-Mice, Nude,
pubmed-meshheading:14998328-Models, Molecular,
pubmed-meshheading:14998328-Naphthalimides,
pubmed-meshheading:14998328-Neoplasm Transplantation,
pubmed-meshheading:14998328-Structure-Activity Relationship,
pubmed-meshheading:14998328-Thiophenes,
pubmed-meshheading:14998328-Transplantation, Heterologous
|
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pubmed:year |
2004
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|
pubmed:articleTitle |
New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.
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|
pubmed:affiliation |
Departamentos de Ciencias Químicas, Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo CEU, Urbanización Montepríncipe, 28668-Boadilla del Monte, Madrid, Spain. mfbrana@ceu.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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