| pubmed-article:14992718 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C1882071 | lld:lifeskim |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C0220922 | lld:lifeskim |
| pubmed-article:14992718 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:14992718 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:14992718 | pubmed:dateCreated | 2004-3-2 | lld:pubmed |
| pubmed-article:14992718 | pubmed:abstractText | To initiate a system-level analysis of C. elegans DAF-7/TGF-beta signaling, we combined interactome mapping with single and double genetic perturbations. Yeast two-hybrid (Y2H) screens starting with known DAF-7/TGF-beta pathway components defined a network of 71 interactions among 59 proteins. Coaffinity purification (co-AP) assays in mammalian cells confirmed the overall quality of this network. Systematic perturbations of the network using RNAi, both in wild-type and daf-7/TGF-beta pathway mutant animals, identified nine DAF-7/TGF-beta signaling modifiers, seven of which are conserved in humans. We show that one of these has functional homology to human SNO/SKI oncoproteins and that mutations at the corresponding genetic locus daf-5 confer defects in DAF-7/TGF-beta signaling. Our results reveal substantial molecular complexity in DAF-7/TGF-beta signal transduction. Integrating interactome maps with systematic genetic perturbations may be useful for developing a systems biology approach to this and other signaling modules. | lld:pubmed |
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| pubmed-article:14992718 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:14992718 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14992718 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:14992718 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:14992718 | pubmed:author | pubmed-author:PandeyAkhiles... | lld:pubmed |
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| pubmed-article:14992718 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:14992718 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14992718 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14992718 | pubmed:pagination | 469-82 | lld:pubmed |
| pubmed-article:14992718 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:14992718 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:14992718 | pubmed:articleTitle | Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. | lld:pubmed |
| pubmed-article:14992718 | pubmed:affiliation | Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:14992718 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14992718 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:14992718 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:14992718 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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