Linked Life Data

14989260

Source:http://linkedlifedata.com/resource/pubmed/id/14989260

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2004-2-27
pubmed:abstractText
The present paper focussed on the mechanistic aspect of the reaction of singlet oxygen (1O2), in its lowest excited state (1 Delta g), toward DNA constituents. It is well known that 1O2 is able to react with the guanine moiety of DNA to produce almost specifically 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo). However, when 2'-deoxyguanosine (dGuo), free in solution, is the substrate, additional modified nucleosides are detected upon 1O2-mediated oxidation. The combined use of the thermolysis of a water-soluble naphthalene endoperoxide as a generator of 18O-singlet oxygen and the sensitivity of electrospray ionization-tandem mass spectrometry has allowed us to better understand the reactivity of 1O2 toward dGuo and 8-oxodGuo. As a striking observation, the secondary oxidation reaction of 8-oxodGuo, a main 1O2 oxidation product of dGuo, may explain, at least partly, the observed mutagenicity of 1O2.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0003-9861
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
423
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
23-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Mechanistic aspects of the oxidation of DNA constituents mediated by singlet molecular oxygen.
pubmed:affiliation
Laboratoire Lésions des Adides Nucléiques Service de Chimie Inorganique et Biologique, FRE 2600, Départemnt de Recherche Fondmentale sur la Matière Condensée, CEA Grenoble, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't