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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2004-2-26
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pubmed:abstractText |
Defects in the apoptotic pathway are a general cause for drug resistance. Chemotherapy in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has proven to be an effective strategy to induce apoptosis in vitro in ovarian tumor cells. Systemic TRAIL administration might be a therapeutic option, since no toxicity was observed in nonhuman primates. In the present study, expression of TRAIL and its apoptosis-inducing death receptors (DR4 and DR5) and inhibitory decoy receptor (DcR1) was studied in normal ovaries and in malignant ovarian tumors before and after chemotherapy to investigate the therapeutic potential of TRAIL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, TNF-Related...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNF-Related Apoptosis-Inducing...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF10A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF10B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF10C protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor Decoy...,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0090-8258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
794-800
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14984943-Apoptosis Regulatory Proteins,
pubmed-meshheading:14984943-Female,
pubmed-meshheading:14984943-GPI-Linked Proteins,
pubmed-meshheading:14984943-Humans,
pubmed-meshheading:14984943-Immunohistochemistry,
pubmed-meshheading:14984943-Membrane Glycoproteins,
pubmed-meshheading:14984943-Neoplasm Staging,
pubmed-meshheading:14984943-Ovarian Neoplasms,
pubmed-meshheading:14984943-Paraffin Embedding,
pubmed-meshheading:14984943-Receptors, TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:14984943-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:14984943-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:14984943-Tumor Necrosis Factor Decoy Receptors,
pubmed-meshheading:14984943-Tumor Necrosis Factor-alpha
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pubmed:year |
2004
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pubmed:articleTitle |
Chemotherapy induces death receptor 5 in epithelial ovarian carcinoma.
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pubmed:affiliation |
Department of Gynecological Oncology, University Hospital, Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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