Source:http://linkedlifedata.com/resource/pubmed/id/14984502
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2004-2-26
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| pubmed:abstractText |
The aim of this study was to evaluate the relationship between factor VIII (FVIII) levels, measured by chromogenic and clotting assays, and risk of venous thromboembolism (VTE) recurrence. A total of 564 patients underwent clinical follow-up after oral anticoagulant withdrawal (total follow-up = 924.4 years). Recurrent VTE developed in 39 of 309 (12.6%) patients with a first idiopathic VTE and in 14 of 255 (5.5%) patients whose first event was secondary. In patients with a first idiopathic VTE, the risk of recurrence was more than fivefold higher in patients with FVIII levels exceeding the 90th percentile [chromogenic FVIII: relative risk (RR) 5.43 (95% CI 1.76-16.8); clotting FVIII: RR 6.21 (95% CI 1.57-24.5)] after adjustment for all possible confounding variables. In patients with a first secondary VTE, the risk of recurrence was slightly higher in patients with high FVIII levels [chromogenic FVIII: RR 2.62 (95% CI 0.34-19.9); clotting FVIII: RR 1.74 (95% CI 0.25-12.1)], but, given the low number of recurrences, the 95% CI were very large. In conclusion, this study shows that high FVIII levels are associated with increased risk of VTE recurrence in patients with a first idiopathic VTE. Although the measurement of FVIII levels by a specific chromogenic assay might, in principle, be preferred to avoid the risk of aspecific clotting effects, no significant differences in results obtained by chromogenic or clotting methods were found.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0007-1048
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
124
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
504-10
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:14984502-Adolescent,
pubmed-meshheading:14984502-Adult,
pubmed-meshheading:14984502-Aged,
pubmed-meshheading:14984502-Aged, 80 and over,
pubmed-meshheading:14984502-Blood Coagulation Tests,
pubmed-meshheading:14984502-Child,
pubmed-meshheading:14984502-Chromogenic Compounds,
pubmed-meshheading:14984502-Factor VIII,
pubmed-meshheading:14984502-Female,
pubmed-meshheading:14984502-Follow-Up Studies,
pubmed-meshheading:14984502-Humans,
pubmed-meshheading:14984502-Male,
pubmed-meshheading:14984502-Middle Aged,
pubmed-meshheading:14984502-Recurrence,
pubmed-meshheading:14984502-Risk Factors,
pubmed-meshheading:14984502-Thromboembolism,
pubmed-meshheading:14984502-Thrombophilia,
pubmed-meshheading:14984502-Venous Thrombosis
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| pubmed:year |
2004
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| pubmed:articleTitle |
High plasma levels of factor VIII and risk of recurrence of venous thromboembolism.
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| pubmed:affiliation |
Unità di Ricerca Clinica sulla Trombofilia "Marino Golinelli"- Dipartimento Cardiovascolare, UO Angiologia e Malattie della Coagulazione, Azienda Ospedaliera di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy. legnanic@tin.it
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| pubmed:publicationType |
Journal Article
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