|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013081,
umls-concept:C0017262,
umls-concept:C0025131,
umls-concept:C0026809,
umls-concept:C0087111,
umls-concept:C0185117,
umls-concept:C0205341,
umls-concept:C0439861,
umls-concept:C0533557,
umls-concept:C0871261,
umls-concept:C0907533,
umls-concept:C1417759,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2004-2-23
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|
pubmed:abstractText |
Unsei-in inhibits substance P (SP)-induced scratching of mice after repeated administration. The involvement of cutaneous nitric oxide (NO) in the SP-induced scratching led us to investigate the effects of Unsei-in on the cutaneous NO system in mice. Seven-day oral administration of Unsei-in (300, but not 100, mg/kg daily) significantly inhibited scratching and the increase of cutaneous NO after intradermal SP injection. The NO synthase 1 (NOS1) inhibitor 7-nitroindazole (1 nmol/site) decreased SP-induced scratching and NO production. Repeated administration of Unsei-in (300 mg/kg) reduced the cutaneous NOS1 level. The results suggest that the inhibition of cutaneous NOS1 expression and NO production participates in the antipruritic action of Unsei-in.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1347-8613
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
94
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
207-10
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14978361-Animals,
pubmed-meshheading:14978361-Dose-Response Relationship, Drug,
pubmed-meshheading:14978361-Down-Regulation,
pubmed-meshheading:14978361-Drugs, Chinese Herbal,
pubmed-meshheading:14978361-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:14978361-Male,
pubmed-meshheading:14978361-Mice,
pubmed-meshheading:14978361-Mice, Inbred ICR,
pubmed-meshheading:14978361-Nitric Oxide Synthase,
pubmed-meshheading:14978361-Nitric Oxide Synthase Type I,
pubmed-meshheading:14978361-Pruritus,
pubmed-meshheading:14978361-Substance P
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|
pubmed:year |
2004
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|
pubmed:articleTitle |
Repeated treatment with the traditional medicine Unsei-in inhibits substance P-induced itch-associated responses through downregulation of the expression of nitric oxide synthase 1 in mice.
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|
pubmed:affiliation |
Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
