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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
307-308
|
| pubmed:dateCreated |
1993-2-16
|
| pubmed:abstractText |
In a prospective study, 100 patients undergoing open heart surgery were randomly allocated to receive ice/slush topical hypothermia for myocardial protection (Group I, n = 56) or not (Group II, n = 44). Chest radiographs, diaphragm screening, lung function and phrenic nerve conduction time were assessed pre-operatively and at 1 week and 1 month post-operatively in all patients and subsequently at 3 months, 6 months, 1 year and 2 years in all patients with radiological evidence of diaphragm paralysis. The two groups were similar in terms of age, sex, diabetes and smoking habits. Cardiopulmonary bypass and aortic cross-clamp times were similar in the two groups. Radiological evidence of partial left lower lobe collapse was more frequent in Group I (79 per cent vs. 36 per cent, p < 0.01). Twenty (36 per cent) Group I patients developed unilateral diaphragm paralysis (19 left-sided) compared with none in Group II. Diaphragm paralysis was still present in 19 patients (34 per cent) at 1 month, in five patients (9 per cent) at 1 year and in one patient (2 per cent) at 2 years post-operatively. Phrenic nerve conduction time was recorded in 98 per cent of patients pre-operatively, but was unrecordable on the appropriate side in all 20 patients with diaphragm paralysis 1 week post-operatively. Prolonged phrenic nerve conduction time on the left side was found in a further seven Group I patients 1 week post-operatively. There were no significant differences between the two groups in terms of post-operative arrhythmias, myocardial infarction or mortality.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0033-5622
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
845-53
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1484946-Aged,
pubmed-meshheading:1484946-Cardiac Surgical Procedures,
pubmed-meshheading:1484946-Cardiopulmonary Bypass,
pubmed-meshheading:1484946-Double-Blind Method,
pubmed-meshheading:1484946-Female,
pubmed-meshheading:1484946-Humans,
pubmed-meshheading:1484946-Hypothermia, Induced,
pubmed-meshheading:1484946-Male,
pubmed-meshheading:1484946-Middle Aged,
pubmed-meshheading:1484946-Neural Conduction,
pubmed-meshheading:1484946-Phrenic Nerve,
pubmed-meshheading:1484946-Prospective Studies,
pubmed-meshheading:1484946-Respiratory Paralysis,
pubmed-meshheading:1484946-Vital Capacity
|
| pubmed:articleTitle |
Phrenic nerve and diaphragm function following open heart surgery: a prospective study with and without topical hypothermia.
|
| pubmed:affiliation |
John Radcliffe Hospital, Headington, Oxford.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|