Source:http://linkedlifedata.com/resource/pubmed/id/14768051
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2004-2-9
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| pubmed:abstractText |
The chemokine receptor CCR7 and its ligands regulate migration and colocalization of T cells and mature dendritic cells to and within secondary lymphoid organs. The requirement of CCR7 in efficient priming of allospecific cytotoxic CD8(+) T cells is poorly characterized. Here, we demonstrate a role for CCR7 in the initiation of an alloimmune response and in the development of transplant rejection. Remarkably, in a model of acute allogeneic tumor rejection, CCR7(-/-) mice completely failed to reject subcutaneously injected MHC class I mismatched tumor cells and cytotoxic activity of allospecific T cells was severely compromised. When solid tumors derived from wild-type mice were transplanted, recipient CCR7(-/-) mice were capable of rejecting the allografts. In contrast, tumor allografts transplanted from CCR7(-/-) donors onto CCR7(-/-) recipients showed allograft survival up to 28 days, suggesting a critical function of CCR7 on donor-type passenger leukocytes in the initiation of cytotoxic CD8(+) T cell responses. In a heterotopic heart transplantation model CCR7 deficiency resulted in significantly prolonged but not indefinite allograft survival. Additional prolongation of graft survival was observed when hearts from CCR7(-/-) mice were used as donor organs. Our results define a key role for CCR7 in allogeneic T cell priming within the context of draining lymph nodes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Ccr7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
0014-2980
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
34
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
461-70
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14768051-Adoptive Transfer,
pubmed-meshheading:14768051-Animals,
pubmed-meshheading:14768051-Antibodies, Neoplasm,
pubmed-meshheading:14768051-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:14768051-Flow Cytometry,
pubmed-meshheading:14768051-Graft Rejection,
pubmed-meshheading:14768051-Graft Survival,
pubmed-meshheading:14768051-Heart Transplantation,
pubmed-meshheading:14768051-Histocompatibility Antigens Class I,
pubmed-meshheading:14768051-Lymph Nodes,
pubmed-meshheading:14768051-Lymphocyte Activation,
pubmed-meshheading:14768051-Male,
pubmed-meshheading:14768051-Mice,
pubmed-meshheading:14768051-Mice, Inbred BALB C,
pubmed-meshheading:14768051-Mice, Inbred C57BL,
pubmed-meshheading:14768051-Mice, Knockout,
pubmed-meshheading:14768051-Receptors, CCR7,
pubmed-meshheading:14768051-Receptors, Chemokine,
pubmed-meshheading:14768051-Survival Analysis,
pubmed-meshheading:14768051-T-Lymphocytes, Cytotoxic
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| pubmed:year |
2004
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| pubmed:articleTitle |
The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses.
|
| pubmed:affiliation |
Department of Tumor Genetics and Immunogenetics, Max-Delbrück-Center for Molecular Medicine, MDC, Berlin, Germany. uhoepken@mdc-berlin.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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