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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5657
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pubmed:dateCreated |
2004-1-23
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pubmed:abstractText |
Unlike major histocompatibility proteins, which bind peptides, CD1 proteins display lipid antigens to T cells. Here, we report that CD1a presents a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. T cell activation was mediated by the alphabeta T cell receptors and was specific for structure of the acyl and peptidic components of these antigens. These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/CD1a antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/mycobactins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:BrennerMichael BMB,
pubmed-author:ChengTan-YunTY,
pubmed-author:CostelloCatherine ECE,
pubmed-author:LeverySteven BSB,
pubmed-author:MillerMarvin JMJ,
pubmed-author:MoodyD BranchDB,
pubmed-author:O'ConnorPeter BPB,
pubmed-author:RosatJean-PierreJP,
pubmed-author:Roura-MirCarmeC,
pubmed-author:WalzAndrewA,
pubmed-author:WilsonIan AIA,
pubmed-author:YoungDavid CDC,
pubmed-author:ZajoncDirk MDM
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
303
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
527-31
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:14739458-Antigen Presentation,
pubmed-meshheading:14739458-Antigens, Bacterial,
pubmed-meshheading:14739458-Antigens, CD1,
pubmed-meshheading:14739458-Cell Line,
pubmed-meshheading:14739458-Chromatography, High Pressure Liquid,
pubmed-meshheading:14739458-Humans,
pubmed-meshheading:14739458-Hydrogen Bonding,
pubmed-meshheading:14739458-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:14739458-Hydroxylation,
pubmed-meshheading:14739458-Lipoproteins,
pubmed-meshheading:14739458-Lymphocyte Activation,
pubmed-meshheading:14739458-Models, Molecular,
pubmed-meshheading:14739458-Mycobacterium tuberculosis,
pubmed-meshheading:14739458-Oxazoles,
pubmed-meshheading:14739458-Protein Conformation,
pubmed-meshheading:14739458-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:14739458-T-Lymphocytes,
pubmed-meshheading:14739458-Transfection
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pubmed:year |
2004
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pubmed:articleTitle |
T cell activation by lipopeptide antigens.
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pubmed:affiliation |
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building Room 514, 1 Jimmy Fund Way, Boston, MA 02115, USA. bmoody@rics.bwh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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