Source:http://linkedlifedata.com/resource/pubmed/id/14715456
| Subject | Predicate | Object | Context |
|---|---|---|---|
| pubmed-article:14715456 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14715456 | lifeskim:mentions | umls-concept:C0026549 | lld:lifeskim |
| pubmed-article:14715456 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:14715456 | lifeskim:mentions | umls-concept:C0001640 | lld:lifeskim |
| pubmed-article:14715456 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:14715456 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:14715456 | lifeskim:mentions | umls-concept:C1521801 | lld:lifeskim |
| pubmed-article:14715456 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:14715456 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:14715456 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:14715456 | pubmed:dateCreated | 2004-1-12 | lld:pubmed |
| pubmed-article:14715456 | pubmed:abstractText | Five experiments were performed to study the effects of the Alpha-adrenoceptor agonists, clonidine and guanfacine, upon spontaneous motor activity in chronically morphine administered DSP4-treated and control rats. DSP4 (2 x 50 mg/kg, with a 10-day interval between injections) and vehicle (distilled water) were injected i.p., on each occasion 30 min after zimeldine (20 mg/kg). Morphine dosages were raised incrementally from 5 mg/kg (Days 1-3), through 10 mg/kg (Days 4-7) and 20 mg/kg (Days 8-14), to 30 mg/kg (Days 15-20). Motor activity testing occurred on Day 21, Day 22 as well as in Experiments II-V, (from 1st morphine injection). DSP4 pretreatment and chronic morphine injections each reduced motor activity during the first 30 min of testing; combined DSP4 and morphine treatment potentiated the hypoactivity. Habituation quotients indicated deficits in habituation to the novel test environment by the Vehicle-morphine (Quoteint2 only) and DSP4-morphine groups. Acute clonidine treatment (0.04 mg/kg s.c.) reduced motor activity during the first 30 min of testing but attenuated or blocked the morphine-induced hypoactivity in DSP4-treated and control rats. During the 60-90 min test period, clonidine, but not guanfacine (0.08 mg/kg), potentiated morphine-induced hyperactivity in control rats; acute clonidine enhanced this effect, whereas acute guanfacine reduced it, in the DSP4-treated rats. The enhanced hyperactivity of morphine-clonidine suggest a cross-sensitivity effect. Naloxone (0.1 mg/kg s.c.), injected after the 1st 30-min of testing, potentiated markely the clonidine-induced elevations of motor activity in morphine-administered control rats; in the DSP4-treated rats, these effects were dramatically potentiated, underlining the cross-sensitivity effect. Acute guanfacine treatment reduced motor activity during the first 30 min of testing but did not attenuate reliably morphine-induced hypoactivity in control or DSP4 rats. Naloxone did not potentiate the guanfacine-induced hyperactivity of morphine-administered control rats but induced a marked enhancement in the DSP4-treated rats, a specific case of cross-reactivity. The major findings pertain to a cross-sensitization effect of morphine upon clonidine-induced motor activity in both DSP4-treated and control rats, and to a lesser extent between morphine and guanfacine in NA-denervated rats only. The results may offer interactive implications for noradrenergic-opiate system functioning that may be of influence under neuropathological conditions. | lld:pubmed |
| pubmed-article:14715456 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14715456 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14715456 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:14715456 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14715456 | pubmed:issn | 1029-8428 | lld:pubmed |
| pubmed-article:14715456 | pubmed:author | pubmed-author:FredrikssonAA | lld:pubmed |
| pubmed-article:14715456 | pubmed:author | pubmed-author:ArcherTT | lld:pubmed |
| pubmed-article:14715456 | pubmed:issnType | lld:pubmed | |
| pubmed-article:14715456 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:14715456 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14715456 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14715456 | pubmed:pagination | 411-32 | lld:pubmed |
| pubmed-article:14715456 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:14715456 | pubmed:articleTitle | Effects of alpha-adrenoceptor agonists in chronic morphine administered DSP4-treated rats: evidence for functional cross-sensitization. | lld:pubmed |
| pubmed-article:14715456 | pubmed:affiliation | University of Göteborg, Department of Psychology, Sweden. trevor.archer@psy.gu.se | lld:pubmed |
| pubmed-article:14715456 | pubmed:publicationType | Journal Article | lld:pubmed |