Linked Life Data

14713125

Source:http://linkedlifedata.com/resource/pubmed/id/14713125

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2004-1-9
pubmed:abstractText
Vascular tone represents the balance between local vasodilator mechanisms which attempt to secure adequate blood flow for metabolic demand and neural vasoconstrictor reflexes attempting to maintain arterial pressure. Hypoxia alters vascular tone, shifting this balance in complex ways. Hypoxic vascular responses are not uniform across vascular beds and the mechanisms of hypoxic vasodilation appear to be tissue specific. In healthy humans, skeletal muscle vascular beds exhibit a graded vasodilation in response to hypoxia despite increases in sympathetic vasoconstrictor nerve activity. Previous studies have documented a number of vasodilator substances or systems that appear to be involved in this hypoxic vasodilation. My colleagues and I have conducted studies on the extent to which sympathetic vasoconstriction can mask hypoxic vasodilation, and how sympathetic vasoconstrictor activity interacts with local factors that mediate hypoxic vasodilation in humans. We have focused largely on beta-adrenergic mediated vasodilation, noting that it produces some of its effects via a nitric oxide (NO) pathway. This review will explore the role of epinephrine in generating skeletal muscle vasodilation. How the many factors that determine vascular tone during hypoxic stress impact on the regulation of arterial pressure and how hypoxic vasodilation is altered in several pathophysiological conditions will be discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
543
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-36
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Hypoxic regulation of blood flow in humans. Skeletal muscle circulation and the role of epinephrine.
pubmed:affiliation
University of Oregon, Eugene 97403-1240, USA. halliwil@uoregon.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't