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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16 Pt 1
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pubmed:dateCreated |
2003-12-16
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pubmed:abstractText |
Clinical and experimental evidence suggest that the p33ING1b candidate tumor suppressor functionally cooperates with p53 in controlling biochemical and biological functions. Because p53 is frequently mutated in brain tumors and the ING1 locus maps to a site of which the loss is associated with gliomas, we analyzed the mutation and expression profiles of ING1B in human brain tumors. Here we present the first report of ING1 expression and mutation analyses in human brain tumor samples and malignant glioma cell lines.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/ING1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5952-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14676120-Astrocytoma,
pubmed-meshheading:14676120-Brain Neoplasms,
pubmed-meshheading:14676120-Cell Cycle Proteins,
pubmed-meshheading:14676120-Cell Nucleus,
pubmed-meshheading:14676120-DNA, Neoplasm,
pubmed-meshheading:14676120-DNA-Binding Proteins,
pubmed-meshheading:14676120-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:14676120-Genes, Tumor Suppressor,
pubmed-meshheading:14676120-Glioma,
pubmed-meshheading:14676120-Growth Inhibitors,
pubmed-meshheading:14676120-Humans,
pubmed-meshheading:14676120-Immunoenzyme Techniques,
pubmed-meshheading:14676120-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:14676120-Mutation, Missense,
pubmed-meshheading:14676120-Nuclear Proteins,
pubmed-meshheading:14676120-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:14676120-Protein Isoforms,
pubmed-meshheading:14676120-Protein Transport,
pubmed-meshheading:14676120-Proteins,
pubmed-meshheading:14676120-RNA, Messenger,
pubmed-meshheading:14676120-RNA, Neoplasm,
pubmed-meshheading:14676120-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:14676120-Subcellular Fractions,
pubmed-meshheading:14676120-Tumor Cells, Cultured,
pubmed-meshheading:14676120-Tumor Suppressor Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Altered subcellular localization and low frequency of mutations of ING1 in human brain tumors.
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pubmed:affiliation |
Department of Medical Biochemistry and Southern Alberta Cancer Research Center, The University of Calgary, Calgary, Alberta, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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