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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-12-11
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pubmed:abstractText |
Ischemia-reperfusion (IR) injury causes myocardial dysfunction in part through intracellular calcium overload. A recently described pharmacologic compound, MCC-135 (5-methyl-2-[1-piperazinyl] benzenesulfonic acid monohydrate, Mitsubishi Pharma Corporation), alters intracellular calcium levels. This project tested the hypothesis that MCC-135 would influence regional myocardial contractility when administered at reperfusion and after a prolonged period of ischemia.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0003-4975
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2054-61; discussion 2061
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14667641-Animals,
pubmed-meshheading:14667641-Benzenesulfonates,
pubmed-meshheading:14667641-Biological Transport,
pubmed-meshheading:14667641-Calcium,
pubmed-meshheading:14667641-Creatine Kinase,
pubmed-meshheading:14667641-Creatine Kinase, MB Form,
pubmed-meshheading:14667641-Heart Rate,
pubmed-meshheading:14667641-Isoenzymes,
pubmed-meshheading:14667641-Myocardial Contraction,
pubmed-meshheading:14667641-Myocardial Reperfusion Injury,
pubmed-meshheading:14667641-Piperazines,
pubmed-meshheading:14667641-Swine,
pubmed-meshheading:14667641-Troponin I
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pubmed:year |
2003
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pubmed:articleTitle |
Modulation of calcium transport improves myocardial contractility and enzyme profiles after prolonged ischemia-reperfusion.
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pubmed:affiliation |
Division of Cardiothoracic Surgery, Medical University of South Carolina, and the Ralph H. Johnson Veteran's Association Medical Center, Charleston, South Carolina, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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