Linked Life Data

14652800

Source:http://linkedlifedata.com/resource/pubmed/id/14652800

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
37-38
pubmed:dateCreated
2003-12-3
pubmed:abstractText
BACKGROUND: B-type natriuretic peptide (BNP) has been proven to be a biochemical marker of severity of congestive heart failure. We are aware of only few papers reporting the association of BNP elevation and pulmonary hypertension (primary, thromboembolic, or as a consequence of chronic obstructive pulmonary disease). Less is known about BNP in patients with acute respiratory distress syndrome (ARDS). CASE DESCRIPTION AND RESULTS: We present the case of a previously healthy 27-year-old man with parapneumonic ARDS and an extraordinarily increased BNP level. The ventricular systolic ejection fraction assessed echocardiographically was normal with no evidence of left ventricular diastolic dysfunction. However, a peak BNP level of >1300 pg/mL (normal <100 pg/mL) was recorded. Repeated BNP values were obtained on nine separate days over a period of 3 weeks of mechanical ventilation. With the respiratory improvement following the inhalation of nitric oxide BNP levels decreased to 113 pg/mL. The possible pathophysiological mechanisms of BNP release are discussed. CONCLUSION: There is evidence for BNP elevation in the absence left ventricular dysfunction. This case is an example of impressively high BNP levels associated with ARDS, probably attributable to right ventricular overload due to increased pulmonary vascular resistance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1424-7860
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
515-8
pubmed:dateRevised
2011-2-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Elevation of B-type natriuretic peptide levels in acute respiratory distress syndrome.
pubmed:affiliation
Department of Internal Medicine, Hospital of St. Gallen, Switzerland. micha.maeder@kssg.ch
pubmed:publicationType
Journal Article, Case Reports