| pubmed-article:14642282 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C0072899 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C0900627 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C1519751 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C1333226 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C1705335 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:14642282 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:14642282 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:14642282 | pubmed:dateCreated | 2003-12-3 | lld:pubmed |
| pubmed-article:14642282 | pubmed:abstractText | PSD-95 is a major scaffolding protein of the postsynaptic density, tethering NMDA- and AMPA-type glutamate receptors to signaling proteins and the neuronal cytoskeleton. Here we show that PSD-95 is regulated by the ubiquitin-proteasome pathway. PSD-95 interacts with and is ubiquitinated by the E3 ligase Mdm2. In response to NMDA receptor activation, PSD-95 is ubiquitinated and rapidly removed from synaptic sites by proteasome-dependent degradation. Mutations that block PSD-95 ubiquitination prevent NMDA-induced AMPA receptor endocytosis. Likewise, proteasome inhibitors prevent NMDA-induced AMPA receptor internalization and synaptically induced long-term depression. This is consistent with the notion that PSD-95 levels are an important determinant of AMPA receptor number at the synapse. These data suggest that ubiquitination of PSD-95 through an Mdm2-mediated pathway is critical in regulating AMPA receptor surface expression during synaptic plasticity. | lld:pubmed |
| pubmed-article:14642282 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14642282 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14642282 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14642282 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14642282 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:ScottJohn DJD | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:BearMark FMF | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:ColledgeMarci... | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:LangebergLore... | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:LuHuaH | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:JinYetaoY | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:SnyderEric... | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:SoderlingJacq... | lld:pubmed |
| pubmed-article:14642282 | pubmed:author | pubmed-author:CrozierRobert... | lld:pubmed |
| pubmed-article:14642282 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14642282 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:14642282 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:14642282 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14642282 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14642282 | pubmed:pagination | 595-607 | lld:pubmed |
| pubmed-article:14642282 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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