Source:http://linkedlifedata.com/resource/pubmed/id/14634088
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2003-11-24
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| pubmed:abstractText |
A strong female predominance is a well-recognized feature of human lupus. The mechanism by which sex influences disease expression and severity is not fully understood. To address this question, we used the parent-into-F(1) (p-->F(1)) model of chronic graft-vs-host disease (cGVHD) in which lupus-like humoral autoimmunity and renal disease are induced in normal F(1) mice. An advantage of this model is that the pathogenic T cells driving disease (donor strain) can be studied separately from nonspecifically activated T cells (host strain). We observed that lupus-like disease using female donor and host mice (f-->F cGVHD) is characterized by more severe long-term disease (glomerulonephritis) than with male donor and host (m-->M cGVHD). Interestingly, differences in disease parameters could be seen at 2 wk after parental cell transfer, as evidenced by a 2- to 3-fold greater engraftment of donor CD4(+) T cells in f-->F cGVHD mice, which persisted throughout disease course. Enhanced engraftment of donor CD4(+) T cells in f-->F cGVHD mice was not due to differences in splenic homing, alloreactive precursor frequency, initial proliferation rates, or apoptotic rates, but rather to sustained high proliferation rates during wk 2 of disease compared with m-->M cGVHD mice. Crossover studies (m-->F, f-->M) demonstrated that enhanced donor CD4(+) T cell proliferation and engraftment segregate with the sex of the host. These results demonstrate that the sex of the recipient can influence the expansion of pathogenic T cells, thus increasing long-term the burden of autoreactive T cells and resulting in greater disease severity.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
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| pubmed:volume |
171
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
5795-801
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| pubmed:dateRevised |
2011-11-14
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| pubmed:meshHeading |
pubmed-meshheading:14634088-Animals,
pubmed-meshheading:14634088-Antigen-Presenting Cells,
pubmed-meshheading:14634088-B-Lymphocyte Subsets,
pubmed-meshheading:14634088-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14634088-Cell Division,
pubmed-meshheading:14634088-Cell Movement,
pubmed-meshheading:14634088-Chronic Disease,
pubmed-meshheading:14634088-Female,
pubmed-meshheading:14634088-Graft Enhancement, Immunologic,
pubmed-meshheading:14634088-Injections, Intravenous,
pubmed-meshheading:14634088-Isoantigens,
pubmed-meshheading:14634088-Lupus Nephritis,
pubmed-meshheading:14634088-Lymphocyte Count,
pubmed-meshheading:14634088-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:14634088-Male,
pubmed-meshheading:14634088-Mice,
pubmed-meshheading:14634088-Mice, Inbred C57BL,
pubmed-meshheading:14634088-Mice, Inbred DBA,
pubmed-meshheading:14634088-Severity of Illness Index,
pubmed-meshheading:14634088-Sex Characteristics,
pubmed-meshheading:14634088-Spleen,
pubmed-meshheading:14634088-Stem Cells,
pubmed-meshheading:14634088-T-Lymphocyte Subsets,
pubmed-meshheading:14634088-Time Factors
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| pubmed:year |
2003
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| pubmed:articleTitle |
Increased severity of murine lupus in female mice is due to enhanced expansion of pathogenic T cells.
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| pubmed:affiliation |
Research Service, Baltimore Veterans Affairs Medical Center, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. tlang001@umaryland.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|