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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1993-1-8
|
| pubmed:abstractText |
We have previously reported the isolation of several temperature-sensitive (ts) mutants of F9 cells. Further investigations showed that some mutants were induced to differentiate at non-permissive temperature of cell growth, accompanied by changes in the expression of various genes, whereas others were not. During the differentiation induced by shifting up to the non-permissive temperature, a rapid and transient decrease in both c-myc and p53 mRNA levels and rapid induction of c-jun mRNA were observed. These changes were specific in differentiation-inducible mutants and were not observed in a non-inducible mutant. In both types of mutants, the level of c-myc mRNA decreased in association with growth retardation at the non-permissive temperature. The p53 mRNA, however, showed specific increase in the differentiation-inducible ts mutants. These observations suggest distinct roles for p53 and c-myc from proliferation to differentiation in teratocarcinoma stem cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:geneSymbol |
c-jun,
c-myc,
p53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2455-60
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1461650-Animals,
pubmed-meshheading:1461650-Blotting, Northern,
pubmed-meshheading:1461650-Cell Differentiation,
pubmed-meshheading:1461650-Cell Division,
pubmed-meshheading:1461650-Gene Expression,
pubmed-meshheading:1461650-Genes, jun,
pubmed-meshheading:1461650-Genes, myc,
pubmed-meshheading:1461650-Genes, p53,
pubmed-meshheading:1461650-Kinetics,
pubmed-meshheading:1461650-Mice,
pubmed-meshheading:1461650-Mutation,
pubmed-meshheading:1461650-RNA, Messenger,
pubmed-meshheading:1461650-RNA, Neoplasm,
pubmed-meshheading:1461650-Temperature,
pubmed-meshheading:1461650-Teratoma,
pubmed-meshheading:1461650-Transcription, Genetic,
pubmed-meshheading:1461650-Tumor Cells, Cultured,
pubmed-meshheading:1461650-Tumor Suppressor Protein p53
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
c-myc and p53 gene expression in the differentiation of temperature-sensitive mutants of teratocarcinoma F9 cells.
|
| pubmed:affiliation |
Research Institute for Microbial Diseases, Dental Faculty, Osaka University, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|