Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2003-11-19
pubmed:abstractText
Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck-interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. Thus, LIME appears to be involved in regulation of T cell activation by coreceptors.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-10026153, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-10209036, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-10458777, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-10790433, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-10801129, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-10838081, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-10925291, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-10952314, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11158295, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11283593, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11293120, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11390365, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11390434, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11420035, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11433379, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11694542, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11805080, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11841937, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11859092, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-11861607, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12055221, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12077249, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12218108, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12359715, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12411311, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12486104, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12514734, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12517957, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12614358, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-12732664, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-1382093, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-1383828, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-14610044, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-2144894, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-2413158, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-2938014, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-3108015, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-3501123, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-7511210, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-7537852, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-9244341, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-9489702, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-9675140, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-9687533, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-9729044, http://linkedlifedata.com/resource/pubmed/commentcorrection/14610046-9826536
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1453-62
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
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