| pubmed-article:14565460 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14565460 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:14565460 | lifeskim:mentions | umls-concept:C0010723 | lld:lifeskim |
| pubmed-article:14565460 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:14565460 | pubmed:issue | 5-8 | lld:pubmed |
| pubmed-article:14565460 | pubmed:dateCreated | 2003-10-20 | lld:pubmed |
| pubmed-article:14565460 | pubmed:abstractText | In order to design new efficient cytidine based drugs, an intersubunit interactions study related to the active site has been performed on the wild-type cytidine deaminase (CDA) and on the mutant enzyme F137W/W113F. F137 is the homologous to the Bacillus subtilis CDA F125 involved in the subunit interactions. In presence of the dissociating agent SDS, wild-type human CDA dissociate into enzymatically inactive monomers without intermediate forms via a non-cooperative transition. Extensive dialysis or dilution of the inactivated monomers restores completely the activity. The presence of the strong human CDA competitive inhibitor 5-fluorozebularine disfavour dissociation of the tetramer into subunits in the wild-type CDA but not in mutant enzyme F137W/W113F. | lld:pubmed |
| pubmed-article:14565460 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14565460 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14565460 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14565460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14565460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14565460 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14565460 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14565460 | pubmed:issn | 1525-7770 | lld:pubmed |
| pubmed-article:14565460 | pubmed:author | pubmed-author:VitiII | lld:pubmed |
| pubmed-article:14565460 | pubmed:author | pubmed-author:MarianiPP | lld:pubmed |
| pubmed-article:14565460 | pubmed:author | pubmed-author:CristalliGG | lld:pubmed |
| pubmed-article:14565460 | pubmed:author | pubmed-author:CostanziSS | lld:pubmed |
| pubmed-article:14565460 | pubmed:author | pubmed-author:VincenzettiSS | lld:pubmed |
| pubmed-article:14565460 | pubmed:author | pubmed-author:QuadriniBB | lld:pubmed |
| pubmed-article:14565460 | pubmed:author | pubmed-author:CammertoniNN | lld:pubmed |
| pubmed-article:14565460 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14565460 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:14565460 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14565460 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14565460 | pubmed:pagination | 1535-8 | lld:pubmed |
| pubmed-article:14565460 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:meshHeading | pubmed-meshheading:14565460... | lld:pubmed |
| pubmed-article:14565460 | pubmed:articleTitle | Intersubunit interactions in human cytidine deaminase. | lld:pubmed |
| pubmed-article:14565460 | pubmed:affiliation | Dipartimento di Scienze Veterinarie, University of Camerino, Matelica (MC), Italy. | lld:pubmed |
| pubmed-article:14565460 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:978 | entrezgene:pubmed | pubmed-article:14565460 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:14565460 | lld:entrezgene |
