| pubmed-article:14522892 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14522892 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:14522892 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:14522892 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:14522892 | lifeskim:mentions | umls-concept:C0596244 | lld:lifeskim |
| pubmed-article:14522892 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:14522892 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:14522892 | lifeskim:mentions | umls-concept:C0282524 | lld:lifeskim |
| pubmed-article:14522892 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:14522892 | pubmed:dateCreated | 2003-10-2 | lld:pubmed |
| pubmed-article:14522892 | pubmed:abstractText | Recent studies suggest that genetic polymorphisms of the estrogen receptor-alpha (ER-alpha) gene may be associated with breast cancer risk. To evaluate the role of this gene in the risk of breast cancer, we genotyped a newly identified GT dinucleotide repeat [(GT)(n)] polymorphism located in the promoter region (6.6 kb upstream of the transcription start site) in 947 breast cancer cases and 993 age frequency-matched community controls from a population-based case-control study conducted among Chinese in urban Shanghai. Sixteen alleles were identified, the most common one having 16 GT repeats [(GT)(16)]. Compared with subjects homozygous for this allele, subjects carrying the (GT)(17) or (GT)(18) allele had a decreased risk of breast cancer. The odds ratios (ORs) were 0.81 [95% confidence interval (CI), 0.62-1.06] and 0.58 (95% CI, 0.36-0.94), respectively, for one and two copies of the (GT)(17) or (GT)(18) allele. The inverse association with carrying either of these alleles was stronger among women with >30 years of menstrual cycles (OR 0.66; 95% CI 0.51-0.85) than those with a shorter duration of menstrual cycles (OR 0.97; 95% CI 0.73-1.27), and the test for an interaction was statistically significant (P = 0.04). Among breast cancer patients, the presence of either the (GT)(17) or (GT)(18) allele was associated with a reduced expression of progesterone receptor. Results of this study indicate that the GT dinucleotide repeat polymorphism in ER-alpha gene promoter region may be a new biomarker for genetic susceptibility to breast cancer. | lld:pubmed |
| pubmed-article:14522892 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14522892 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14522892 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14522892 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14522892 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14522892 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:14522892 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14522892 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:14522892 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:14522892 | pubmed:author | pubmed-author:GUYM JMJ | lld:pubmed |
| pubmed-article:14522892 | pubmed:author | pubmed-author:ZhengWeiW | lld:pubmed |
| pubmed-article:14522892 | pubmed:author | pubmed-author:SmithJeffrey... | lld:pubmed |
| pubmed-article:14522892 | pubmed:author | pubmed-author:GaoYu-TangYT | lld:pubmed |
| pubmed-article:14522892 | pubmed:author | pubmed-author:ShuXiao-OuXO | lld:pubmed |
| pubmed-article:14522892 | pubmed:author | pubmed-author:WenWanqingW | lld:pubmed |
| pubmed-article:14522892 | pubmed:author | pubmed-author:CaiQiuyinQ | lld:pubmed |
| pubmed-article:14522892 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14522892 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:14522892 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:14522892 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14522892 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14522892 | pubmed:pagination | 5727-30 | lld:pubmed |
| pubmed-article:14522892 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:14522892 | pubmed:meshHeading | pubmed-meshheading:14522892... | lld:pubmed |
| pubmed-article:14522892 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14522892 | pubmed:articleTitle | Association of breast cancer risk with a GT dinucleotide repeat polymorphism upstream of the estrogen receptor-alpha gene. | lld:pubmed |
| pubmed-article:14522892 | pubmed:affiliation | Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA. qiuyin.cai@vanderbilt.edu | lld:pubmed |
| pubmed-article:14522892 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14522892 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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