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rdf:type |
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lifeskim:mentions |
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0030956,
umls-concept:C0033684,
umls-concept:C0085106,
umls-concept:C0086418,
umls-concept:C0871261,
umls-concept:C1441547,
umls-concept:C1511636,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
1-2
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pubmed:dateCreated |
2003-9-26
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pubmed:abstractText |
Anti-Hu syndrome is a paraneoplastic neurologic disease seemingly associated with an efficient antitumoral immune response against HuD protein expressed by both small cell lung cancer (SCLC) and neurons. Since anti-Hu antibodies are not pathogenic, and oligoclonal CD8(+) T cells infiltrate neoplastic and nervous tissues, we examined MHC class I-restricted immunogenicity of human HuD. Among 14 HuD-derived peptides potentially immunogenic in HLA-A*0201 restriction, 10 had actual in vitro binding capacity to the HLA molecule, 8 elicited specific cytotoxic T lymphocytes (CTLs) in a humanized murine model after peptidic vaccination, 2 also elicited specific CTLs in healthy humans, and 1 was naturally processed and presented to the immune system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/ELAVL4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Elavl4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A*02:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Hu Paraneoplastic...,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Subunit
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:Delfau-LarueMarie HélèneMH,
pubmed-author:FarcetJean PierreJP,
pubmed-author:FernandezEricE,
pubmed-author:Garcia-PonsFranciscoF,
pubmed-author:GherardiRomain KRK,
pubmed-author:KosmatopoulosKonstantinosK,
pubmed-author:Langlade-DemoyenPierreP,
pubmed-author:LemonnierFrançoisF,
pubmed-author:MarquetJeanineJ,
pubmed-author:PhilippeCaramelleC,
pubmed-author:PlonquetAnneA,
pubmed-author:RouardHélèneH
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pubmed:issnType |
Print
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-100
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:14512168-Animals,
pubmed-meshheading:14512168-Antigen Presentation,
pubmed-meshheading:14512168-Antigens, Neoplasm,
pubmed-meshheading:14512168-Cell Line, Tumor,
pubmed-meshheading:14512168-Cytotoxicity, Immunologic,
pubmed-meshheading:14512168-HLA-A Antigens,
pubmed-meshheading:14512168-HLA-A2 Antigen,
pubmed-meshheading:14512168-Hu Paraneoplastic Encephalomyelitis Antigens,
pubmed-meshheading:14512168-Humans,
pubmed-meshheading:14512168-Injections, Intramuscular,
pubmed-meshheading:14512168-Mice,
pubmed-meshheading:14512168-Mice, Knockout,
pubmed-meshheading:14512168-Mice, Transgenic,
pubmed-meshheading:14512168-Nerve Tissue Proteins,
pubmed-meshheading:14512168-Paraneoplastic Syndromes, Nervous System,
pubmed-meshheading:14512168-Peptide Fragments,
pubmed-meshheading:14512168-Protein Binding,
pubmed-meshheading:14512168-RNA-Binding Proteins,
pubmed-meshheading:14512168-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:14512168-Vaccines, Subunit
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pubmed:year |
2003
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pubmed:articleTitle |
Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human.
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pubmed:affiliation |
EA 2348, Université Paris XII, Immunologie Biologique, Hôpital Henri-Mondor, AP-HP, 94010 Créteil, France. anne.plonquet@hmn.ap-hop-paris.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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