| pubmed-article:14510697 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:14510697 | lifeskim:mentions | umls-concept:C1519606 | lld:lifeskim |
| pubmed-article:14510697 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:14510697 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:14510697 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:14510697 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:14510697 | lifeskim:mentions | umls-concept:C0546881 | lld:lifeskim |
| pubmed-article:14510697 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:14510697 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:14510697 | pubmed:dateCreated | 2003-9-26 | lld:pubmed |
| pubmed-article:14510697 | pubmed:abstractText | We have developed an adoptive transfer model system to visualize the dynamics of alloantigen-specific CD4+ T-cell activation in vivo. Using TCR-transgenic (tg) mice reactive to I-Ab(m12), we studied the clonal expansion and differentiation of alloreactive T cells by tracking the fate of adoptively transferred TCR-tg CD4+ T cells in syngeneic mice transplanted with skin grafts expressing I-Ab(m12). Following transplantation, alloantigen-specific TCR-tg CD4+ T-cell expansion was observed initially in the draining lymph nodes followed by the spleen. TCR-tg CD4+ T cells up-regulated CD69 and CD25 expression, developed an effector/memory surface phenotype and produced IFN-gamma in response to alloantigen ex vivo. Furthermore, we validate the model system as a means for studying the effects of tolerogenic regimens on alloreactive CD4+ T cells, demonstrating that CTLA4Ig inhibits alloantigen-dependent clonal expansion and effector function of TCR-tg CD4+ T cells in vivo. We describe the first model for tracking alloreactive CD4+ T-cell activation in vivo. It provides a powerful tool for studying CD4+ T-cell mediated alloimmune responses and mechanisms of tolerance induction in vivo. | lld:pubmed |
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| pubmed-article:14510697 | pubmed:language | eng | lld:pubmed |
| pubmed-article:14510697 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:14510697 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:14510697 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:14510697 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:14510697 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:14510697 | pubmed:issn | 1600-6135 | lld:pubmed |
| pubmed-article:14510697 | pubmed:author | pubmed-author:SalamaAlan... | lld:pubmed |
| pubmed-article:14510697 | pubmed:author | pubmed-author:SayeghMohamed... | lld:pubmed |
| pubmed-article:14510697 | pubmed:author | pubmed-author:TurkaLaurence... | lld:pubmed |
| pubmed-article:14510697 | pubmed:author | pubmed-author:HouserStuart... | lld:pubmed |
| pubmed-article:14510697 | pubmed:author | pubmed-author:PalmerEdE | lld:pubmed |
| pubmed-article:14510697 | pubmed:author | pubmed-author:SandnerSigrid... | lld:pubmed |
| pubmed-article:14510697 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:14510697 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:14510697 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:14510697 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:14510697 | pubmed:pagination | 1242-50 | lld:pubmed |
| pubmed-article:14510697 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:14510697 | pubmed:meshHeading | pubmed-meshheading:14510697... | lld:pubmed |
| pubmed-article:14510697 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:14510697 | pubmed:articleTitle | New TCR transgenic model for tracking allospecific CD4 T-cell activation and tolerance in vivo. | lld:pubmed |
| pubmed-article:14510697 | pubmed:affiliation | Division of Nephrology, The Children's Hospital, Harvard Medical School, Boston, MA, USA. | lld:pubmed |
| pubmed-article:14510697 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:14510697 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:14961 | entrezgene:pubmed | pubmed-article:14510697 | lld:entrezgene |
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