Source:http://linkedlifedata.com/resource/pubmed/id/14504945
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3-4
|
| pubmed:dateCreated |
2003-11-7
|
| pubmed:abstractText |
Altitude hypoxia is a major challenge to the blood O2 transport system, and adjustments of the blood-O2 affinity might contribute significantly to hypoxia adaptation. In principle, lowering the blood-O2 affinity is advantageous because it lowers the circulatory load required to assure adequate tissue oxygenation up to a threshold corresponding to about 5,000 m altitude, whereas at higher altitudes an increased blood-O2 affinity appears more advantageous. However, the rather contradictory experimental evidence raises the question whether other factors superimpose on the apparent changes of the blood-O2 affinity. The most important of these are as follows: (1) absolute temperature and temperature gradients within the body; (2) the intracapillary Bohr effect; (3) the red cell population heterogeneity in terms of O2 affinity; (4) control of altitude alkalosis; (5) the possible role of hemoglobin as a carrier of the vasodilator nitric oxide; (6) the effect of varied red cell transit times through the capillaries.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1439-6319
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
90
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
351-9
|
| pubmed:dateRevised |
2005-11-16
|
| pubmed:meshHeading |
pubmed-meshheading:14504945-Allosteric Regulation,
pubmed-meshheading:14504945-Altitude,
pubmed-meshheading:14504945-Animals,
pubmed-meshheading:14504945-Anoxia,
pubmed-meshheading:14504945-Carbon Dioxide,
pubmed-meshheading:14504945-Cardiac Output,
pubmed-meshheading:14504945-Diffusion,
pubmed-meshheading:14504945-Erythrocyte Aging,
pubmed-meshheading:14504945-Erythrocytes,
pubmed-meshheading:14504945-Hemoglobins,
pubmed-meshheading:14504945-Humans,
pubmed-meshheading:14504945-Hydrogen-Ion Concentration,
pubmed-meshheading:14504945-Models, Molecular,
pubmed-meshheading:14504945-Nitric Oxide,
pubmed-meshheading:14504945-Oxygen,
pubmed-meshheading:14504945-Partial Pressure,
pubmed-meshheading:14504945-Protein Binding,
pubmed-meshheading:14504945-Temperature
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Oxygen transport in blood at high altitude: role of the hemoglobin-oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function.
|
| pubmed:affiliation |
Dipartimento di Medicina, Chirurgia e Odontoiatria, Ospedale San Paolo, Universita' Di Milano, via di Rudini' 8, 20142 Milan, Italy. Michele.Samaja@unimi.it
|
| pubmed:publicationType |
Journal Article,
Review
|