Linked Life Data

14499855

Source:http://linkedlifedata.com/resource/pubmed/id/14499855

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-9-22
pubmed:abstractText
Erythropoietin is a hypoxia-induced hormone that is essential for normal erythropoiesis. The production of recombinant human erythropoietin (rHuEpo) has revolutionized the treatment of anemia associated with chronic renal failure and chemotherapy, and has been used as prophylaxis to prevent anemia after surgery. The erythropoietin receptor is widely distributed in the cardiovascular system, including endothelial cells, smooth muscle cells and cardiomyocytes. Epo has potentially beneficial effects on the endothelium including anti-apoptotic, mitogenic and angiogenic activities. On the other hand, some reports suggest that rHuEpo may have pro-thrombotic or platelet-activating effects. Hypertension develops in 20-30% of renal patients treated with rHuEpo. Many patients with heart failure have anemia. Despite some potential adverse effects, early studies in heart failure patients with anemia suggest that rHuEpo therapy is safe and effective in reducing left ventricular hypertrophy, enhancing exercise performance and increasing ejection fraction. Further studies are warranted to define the role of rHuEpo in chronic heart failure and other cardiovascular settings.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-6363
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
538-48
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:14499855-Anemia, pubmed-meshheading:14499855-Cardiovascular System, pubmed-meshheading:14499855-Cell Division, pubmed-meshheading:14499855-Endothelium, Vascular, pubmed-meshheading:14499855-Erythropoietin, pubmed-meshheading:14499855-GTP-Binding Protein alpha Subunits, Gs, pubmed-meshheading:14499855-Heart Failure, pubmed-meshheading:14499855-Humans, pubmed-meshheading:14499855-Hypertension, pubmed-meshheading:14499855-Kidney Failure, Chronic, pubmed-meshheading:14499855-Muscle, Smooth, Vascular, pubmed-meshheading:14499855-Myocytes, Cardiac, pubmed-meshheading:14499855-Nerve Tissue Proteins, pubmed-meshheading:14499855-Platelet Activation, pubmed-meshheading:14499855-Receptors, Erythropoietin, pubmed-meshheading:14499855-Recombinant Proteins, pubmed-meshheading:14499855-Thrombosis
pubmed:year
2003
pubmed:articleTitle
The cardiovascular effects of erythropoietin.
pubmed:affiliation
Section of Cardiology, Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1045, USA.
pubmed:publicationType
Journal Article, Review