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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1965-5-1
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pubmed:abstractText |
The 7S gamma-globulins causing erythrocyte autosensitization in 20 patients were isolated by elution and examined for homogeneity or heterogeneity of their L chain types and electrophoretic dispersion. The isolated erythrocyte autoantibodies from 12 patients contained only 1 detectable L chain type. Two of these "monotypic" populations showed appreciable restriction of electrophoretic dispersion, while 2 others more nearly resembled the electrophoretic heterogeneity of normal gamma-globulins. The autoantibodies from the other 8 patients exhibited L chains of both types. The single "bitypic" population so tested was relatively polydisperse electrophoretically. As a comparison, anti-Rh(o) isoantibodies from 5 of 6 donors without known hematologic disease showed bitypic reactions, and 2 of these isoantibody populations were relatively polydisperse electrophoretically. One Rh isoantibody is described which contained only 1 demonstrable L chain type. The structural similarities to "paraproteins" observed in a significant proportion of these erythrocyte autoantibodies raise the possibility of their origin from a restricted population of antibody forming cells, and may have implications concerning the pathogenesis of erythrocyte autosensitization.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13212054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13262900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13304841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13579002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13701434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13725658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13725659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13783919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13889153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-13991883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14063859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14078985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14080329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14082031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14087623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14129715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14161012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14169351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14416397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14463404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14482809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14494010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-14908073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-16695905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-18144396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-19867218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14253485-19867222
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/ANTIBODIES,
http://linkedlifedata.com/resource/pubmed/keyword/ANTIGENS,
http://linkedlifedata.com/resource/pubmed/keyword/AUTOIMMUNE DISEASES,
http://linkedlifedata.com/resource/pubmed/keyword/ERYTHROCYTES,
http://linkedlifedata.com/resource/pubmed/keyword/GAMMA GLOBULIN,
http://linkedlifedata.com/resource/pubmed/keyword/GAMMA GLOBULIN, 7S,
http://linkedlifedata.com/resource/pubmed/keyword/GEL DIFFUSION TESTS,
http://linkedlifedata.com/resource/pubmed/keyword/HEMAGGLUTINATION,
http://linkedlifedata.com/resource/pubmed/keyword/IMMUNOELECTROPHORESIS,
http://linkedlifedata.com/resource/pubmed/keyword/ISOANTIBODIES,
http://linkedlifedata.com/resource/pubmed/keyword/MULTIPLE MYELOMA,
http://linkedlifedata.com/resource/pubmed/keyword/RH FACTORS
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
OM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-17
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pubmed:dateRevised |
2010-9-20
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pubmed:meshHeading |
pubmed-meshheading:14253485-Antibodies,
pubmed-meshheading:14253485-Antigens,
pubmed-meshheading:14253485-Autoimmune Diseases,
pubmed-meshheading:14253485-Erythrocytes,
pubmed-meshheading:14253485-Hemagglutination,
pubmed-meshheading:14253485-Immunodiffusion,
pubmed-meshheading:14253485-Immunoelectrophoresis,
pubmed-meshheading:14253485-Immunoglobulin G,
pubmed-meshheading:14253485-Isoantibodies,
pubmed-meshheading:14253485-Multiple Myeloma,
pubmed-meshheading:14253485-Rh-Hr Blood-Group System,
pubmed-meshheading:14253485-gamma-Globulins
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pubmed:year |
1965
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pubmed:articleTitle |
STRUCTURAL ASPECTS OF HUMAN ERYTHROCYTE AUTOANTIBODIES. I. L CHAIN TYPES AND ELECTROPHORETIC DISPERSION.
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pubmed:publicationType |
Journal Article
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