Linked Life Data

14189911

Source:http://linkedlifedata.com/resource/pubmed/id/14189911

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1964-12-1
pubmed:abstractText
A reliable knowledge of the thickness of the alveolo-capillary "membrane" or air-blood barrier is of physiologic interest since it is intimately related to a quantitative estimation of such functional events as gas diffusion or tissue metabolism in the lung. The characteristic thickness of the air-blood barrier with respect to gas diffusion is its harmonic mean thickness, while the arithmetic mean thickness is related to the mass of tissue building the barrier and consuming oxygen in the lung. Two morphometric methods are proposed by which these two dimensions can be estimated from random measurements in the electron microscope in a reliable, simple, and efficient manner. By applying these methods to three rat lungs the arithmetic mean thickness of the barrier was found to measure 1.25 micro, the harmonic mean thickness, 0.57 micro. On the basis of these measurements a geometric model of the barrier in the form of a corrugated membrane was derived. Its dimensions showed close similarity to those of the natural barrier. This analysis suggested furthermore that the gas conductance of the barrier is nearly optimal if one considers the mass of tissue and the minimal barrier thickness as fixed properties which are determined by other functional requirements on the alveolo-capillary membrane.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-13104990, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-13338626, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-13346602, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-13484471, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-13764136, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-13975866, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-13999512, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-14005590, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-14454024, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-14888621, http://linkedlifedata.com/resource/pubmed/commentcorrection/14189911-17838566
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
367-96
pubmed:dateRevised
2010-9-21
pubmed:meshHeading
pubmed:year
1964
pubmed:articleTitle
A MORPHOMETRIC STUDY ON THE THICKNESS OF THE PULMONARY AIR-BLOOD BARRIER.
pubmed:publicationType
Journal Article