Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1977-8-12
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--analysis,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Effectiveness,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive...,
http://linkedlifedata.com/resource/pubmed/keyword/Diethylstilbestrol,
http://linkedlifedata.com/resource/pubmed/keyword/Economic Factors,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Medroxyprogesterone Acetate,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives...,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Low-dose,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives, Phasic,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives--pharmacodynamics,
http://linkedlifedata.com/resource/pubmed/keyword/PROGESTERONE,
http://linkedlifedata.com/resource/pubmed/keyword/Research And Development,
http://linkedlifedata.com/resource/pubmed/keyword/TECHNOLOGY,
http://linkedlifedata.com/resource/pubmed/keyword/Testosterone,
http://linkedlifedata.com/resource/pubmed/keyword/Use-effectiveness
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0004-1858
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
63-7
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:otherAbstract |
PIP: Currently available forms of hormonal contraceptives with regard to their mechanism of action, effectiveness, and side effects are reviewed. The effectiveness of an oral contraceptive in preventing pregnancy is directly related to its ability to inhibit ovulation. Other effects are less important. The development of synthetic progestational agents made inhibition of ovulation possible without unacceptable side effects. The chemical structures of several estrogens are shown and their relationship to natural estrogen indicated. The chemical structures of synthetic progestational agents and their relationship to progesterone and testosterone are illustrated. Diethylstilbestrol is a nonsteroidal estrogenic compound with a potency of 1/25 of that of ethinyl estradiol. It is used only as a postcoital contraceptive for occasional use. Medroxyprogesterone acetate is a long-lasting injectable contraceptive agent. Available oral contraceptive preparations are listed by brand names, hormone content, and tablet amount. With combination compounds a 28-day routine of therapy has been established. In recently developed compounds the amount of hormone used has been reduced so that side effects are less. The pregnancy rate is less than .1%. The very low-dose preparations have a higher pregnancy rate and an increased incidence of intermenstrual bleeding. The sequential-type oral contraceptive is no longer available. The progestin-only type contains no estrogen, and they are taken continuously. They do not prevent ovulation. Their contraceptive effect is by alterations in cervical mucus and endometrial or tubal physiology. The pregnancy rate is relatively high. No single preparation is considered as suitable for all women. Patients with varicose veins or previous thromboembolic phenomena should not use any oral contraceptive. The combination preparations are most suitable for the majority of women.
|
| pubmed:meshHeading |
pubmed-meshheading:141441-Chemical Phenomena,
pubmed-meshheading:141441-Chemistry,
pubmed-meshheading:141441-Contraceptives, Oral,
pubmed-meshheading:141441-Contraceptives, Oral, Hormonal,
pubmed-meshheading:141441-Estrogens,
pubmed-meshheading:141441-Female,
pubmed-meshheading:141441-Humans,
pubmed-meshheading:141441-Progestins
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Hormonal contraception: current perspectives. Part I. An analysis of available agents.
|
| pubmed:publicationType |
Journal Article
|