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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1992-11-10
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pubmed:abstractText |
Interleukin 1 (IL-1) is a cytokine released during immune activation that mediates the host's response to infection and inflammation. Peripheral and central injections of IL-1 induce fever and sickness behavior, including decreased food motivation and reduced interest in social activities. To determine the receptor mechanisms responsible for these effects, rats were injected with IL-1 receptor antagonist (IL-1ra), an endogenous cytokine that acts as a pure antagonist of IL-1 receptors. IL-1ra blocked the increased body temperature and oxygen consumption induced by injection of recombinant human IL-1 only when both cytokines were administered i.p. In contrast, i.p. or intracerebroventricular administration of IL-1ra blocked the depressive effect of IL-1 beta on food-motivated behavior and social exploration when this cytokine was administered by the same route as the antagonist. In addition, intracerebroventricular IL-1ra blocked the reduction in social exploration produced by i.p. IL-1 beta but had only partial antagonist effects on the decrease in food-motivated behavior induced by i.p. IL-1 beta. In each case, the dose of IL-1ra was 100- to 1000-fold in excess of the biologically active dose of IL-1. These results suggest that the receptor mechanisms that mediate the behavioral and pyrogenic effects of IL-1 are heterogeneous.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1184527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1542935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1660748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1825231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1825458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1826128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1826616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1833184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1834644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1967907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-1986393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2097573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2137200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2137201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2139669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2147233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2147409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2147937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2151767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2211833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2357520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2443979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2530579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2568569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2620696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2783532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2786888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-2821621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-3050629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-3258444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-3259449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-3277884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-3520613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-3739372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-6332129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-6365250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409612-6611091
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9117-20
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1409612-Animals,
pubmed-meshheading:1409612-Body Temperature Regulation,
pubmed-meshheading:1409612-Cerebral Ventricles,
pubmed-meshheading:1409612-Exploratory Behavior,
pubmed-meshheading:1409612-Feeding Behavior,
pubmed-meshheading:1409612-Injections, Intraperitoneal,
pubmed-meshheading:1409612-Injections, Intraventricular,
pubmed-meshheading:1409612-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:1409612-Interleukin-1,
pubmed-meshheading:1409612-Male,
pubmed-meshheading:1409612-Oxygen Consumption,
pubmed-meshheading:1409612-Pyrogens,
pubmed-meshheading:1409612-Rats,
pubmed-meshheading:1409612-Rats, Sprague-Dawley,
pubmed-meshheading:1409612-Rats, Wistar,
pubmed-meshheading:1409612-Receptors, Interleukin-1,
pubmed-meshheading:1409612-Recombinant Proteins,
pubmed-meshheading:1409612-Sialoglycoproteins
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pubmed:year |
1992
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pubmed:articleTitle |
Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1.
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pubmed:affiliation |
Institut National de la Recherche Agronomique-Institut National de la Santé et de la Recherche Médicale U176, Bordeaux, France.
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pubmed:publicationType |
Journal Article,
Comparative Study
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