| pubmed-article:1406975 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1406975 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:1406975 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:1406975 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:1406975 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:1406975 | pubmed:issue | 6395 | lld:pubmed |
| pubmed-article:1406975 | pubmed:dateCreated | 1992-11-13 | lld:pubmed |
| pubmed-article:1406975 | pubmed:abstractText | Apoptosis is a form of physiological cell death, characterized by chromatin condensation, cytoplasmic blebbing and DNA fragmentation, which often depends on RNA and protein synthesis by the dying cell. The c-myc proto-oncogene, usually implicated in cell transformation, differentiation and cell-cycle progression also has a central role in some forms of apoptosis. These opposing roles of myc in cell growth and death require that other gene products dictate the outcome of c-Myc expression on a cell. A candidate for such a modifying gene is bcl-2, whose product prolongs cell survival and blocks apoptosis in some systems. Here we demonstrate that Bcl-2 prevents apoptotic death induced by c-Myc, provide a mechanism whereby cells can express c-Myc without undergoing apoptosis, and give a possible explanation for the ability of Bcl-2 to synergize with c-Myc in cell transformation. | lld:pubmed |
| pubmed-article:1406975 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1406975 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1406975 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1406975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1406975 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1406975 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1406975 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1406975 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:1406975 | pubmed:author | pubmed-author:GreenD RDR | lld:pubmed |
| pubmed-article:1406975 | pubmed:author | pubmed-author:BissonnetteR... | lld:pubmed |
| pubmed-article:1406975 | pubmed:author | pubmed-author:MahboubiAA | lld:pubmed |
| pubmed-article:1406975 | pubmed:author | pubmed-author:EcheverriFF | lld:pubmed |
| pubmed-article:1406975 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1406975 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:1406975 | pubmed:volume | 359 | lld:pubmed |
| pubmed-article:1406975 | pubmed:geneSymbol | c-myc | lld:pubmed |
| pubmed-article:1406975 | pubmed:geneSymbol | bcl-2 | lld:pubmed |
| pubmed-article:1406975 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1406975 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1406975 | pubmed:pagination | 552-4 | lld:pubmed |
| pubmed-article:1406975 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1406975 | pubmed:meshHeading | pubmed-meshheading:1406975-... | lld:pubmed |
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| pubmed-article:1406975 | pubmed:meshHeading | pubmed-meshheading:1406975-... | lld:pubmed |
| pubmed-article:1406975 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1406975 | pubmed:articleTitle | Apoptotic cell death induced by c-myc is inhibited by bcl-2. | lld:pubmed |
| pubmed-article:1406975 | pubmed:affiliation | Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, California 92037. | lld:pubmed |
| pubmed-article:1406975 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1406975 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1406975 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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