Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-10-26
|
| pubmed:abstractText |
A major problem in the analysis of nitroglycerin (propanetriol trinitrate, GTN) and its metabolites [propanetriol 1,2-dinitrate (1,2-GDN) and propanetriol 1,3-dinitrate (1,3-GDN)] has been the adsorption of the nitro compounds to glass apparatus during sample preparation or injection. In this paper we present a method determining GTN, 1,2-GDN and 1,3-GDN in plasma at low nanomolar level using capillary gas chromatography with electron-capture detection. The detection limits are about 0.2 nM in plasma. Adsorption of the nitro compounds to glassware is prevented by using triethylamine, giving a simple sample preparation and accurate results. Thus, the laborious and time-consuming silanization of the glassware is avoided.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0021-9673
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
577
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
167-70
|
| pubmed:dateRevised |
2007-10-3
|
| pubmed:meshHeading | |
| pubmed:year |
1992
|
| pubmed:articleTitle |
Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection.
|
| pubmed:affiliation |
Pharmacokinetic Laboratory, Dumex Ltd., Copenhagen, Denmark.
|
| pubmed:publicationType |
Journal Article
|