Linked Life Data

1397738

Source:http://linkedlifedata.com/resource/pubmed/id/1397738

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-11-19
pubmed:abstractText
The mechanisms involved in the relaxation of the lower oesophageal sphincter induced by distension of the oesophagus and different parts of the stomach, were studied in an anaesthetized porcine model. A computer technique was developed allowing on-line digitizing of lower oesophageal sphincter (sleeve device) and intragastric pressures. Basal sphincter tone was slightly reduced by truncal vagotomy, an effect which seemed to be reversed by sectioning of the vagosympathetic trunks in the neck. Balloon distension of the body of the oesophagus, relaxed the sphincter irrespective of the denervation procedures carried out. Distension of the whole stomach with increasing amounts of air induced a dose-dependent relaxatory lower oesophageal sphincter response, which was also closely associated with the subsequent increases in intragastric pressure. Denervation procedures did not alter this dose-response relationship. The importance of intramural mechanisms was illustrated by the abolition of distension-induced effects in most animals studied after transection of the gastro-oesophageal junction distal to the sphincter. Balloon distension of the antrum elicited a smaller but significant sphincter relaxation, but the mechanisms behind this response seemed to be more complex than after insufflation of air.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0012-2823
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-25
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Nervous control of distension-induced relaxation of the porcine lower oesophageal sphincter.
pubmed:affiliation
Department of Surgery, Royal Adelaide Hospital, University of Adelaide, Australia.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't