Linked Life Data

1391677

Source:http://linkedlifedata.com/resource/pubmed/id/1391677

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1992-11-25
pubmed:abstractText
The essential parameter to estimate the first dose size of a drug in man is the volume of distribution. For a drug that has never been used in man before, estimates of the volume of distribution can only be obtained from animals and in vitro data. The purpose of this study was to compare various approaches presented in the literature for predicting the volume of distribution at steady state (VSS) and the terminal phase volume of distribution (Vd beta) in man. A lipophilic active metabolite of coumarin, 7-hydroxycoumarin (7OHC), was selected for this investigation. This compound is extensively metabolized in both the central and peripheral compartments. Of the six methods evaluated, only an empirical allometric approach yielded a reasonable estimate of VSS. All methods underestimated VSS and none of the applicable methods were able to predict Vd beta. The reason for this discrepancy may be due to the fact that the calculation of VSS in man was done assuming elimination from the central compartment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0142-2782
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
389-402
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Prediction of the volume of distribution of 7-hydroxycoumarin in man from in vitro and ex vivo data obtained in rat.
pubmed:affiliation
Division of Pharmaceutics, College of Pharmacy, University of Cincinnati Medical Center, OH 45267-004.
pubmed:publicationType
Journal Article