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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-8-5
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pubmed:abstractText |
Seventy-five squamous cell carcinomas of the head and neck were analysed for c-erbB-2 expression using immunohistochemical techniques with four different c-erbB-2 antibodies. No membrane staining was seen in any of the squamous cell carcinomas studied with any of the antibodies; however, c-erbB-2 cytoplasmic staining was seen in 60 per cent of the tumours. The significance of cytoplasmic staining is discussed and that it may possibly represent elevated c-erbB-2 expression in squamous cell carcinomas. C-erbB-2 cytoplasmic staining was also observed in 10 of 23 normal specimens obtained from the resection margin of the tumours. No correlations were found between positive c-erbB-2 cytoplasmic staining and any of the clinicopathological parameters or survival.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
613-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1377893-Carcinoma, Squamous Cell,
pubmed-meshheading:1377893-Cytoplasm,
pubmed-meshheading:1377893-Follow-Up Studies,
pubmed-meshheading:1377893-Head and Neck Neoplasms,
pubmed-meshheading:1377893-Humans,
pubmed-meshheading:1377893-Immunoenzyme Techniques,
pubmed-meshheading:1377893-Immunohistochemistry,
pubmed-meshheading:1377893-Neoplasm Staging,
pubmed-meshheading:1377893-Prognosis,
pubmed-meshheading:1377893-Proto-Oncogene Proteins,
pubmed-meshheading:1377893-Proto-Oncogenes,
pubmed-meshheading:1377893-Receptor, erbB-2,
pubmed-meshheading:1377893-Staining and Labeling,
pubmed-meshheading:1377893-Time Factors,
pubmed-meshheading:1377893-Tumor Markers, Biological
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pubmed:articleTitle |
C-erbB-2 expression in squamous cell carcinoma of the head and neck.
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pubmed:affiliation |
Department of Clinical Dental Sciences, School of Dentistry, University of Liverpool, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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