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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1992-9-18
|
| pubmed:abstractText |
In a preliminary study we have shown that optimally collected human umbilical cord (HUC) blood cells grow significantly better in long term cultures (LTC) than normal adult marrow cells (NBM) p = 0.0007. The LTC findings are supported by the observation in clonogenic assay that a similar number of GM-CFC colonies can be grown from HUC blood and NBM mononuclear cells (MNC). Also there is a trend towards a higher proportion of primitive erythroid (BFU-E) and primitive megakaryocyte colonies (MK-CFC containing greater than 20 cells) in HUC blood compared with NBM. We suggest that further work on the feasibility of a HLA typed, cryopreserved HUC blood bank as a source of unrelated haemopoietic 'stem' cells for clinical transplantation is indicated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9 Suppl 1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
105-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1354517-Blood Cell Count,
pubmed-meshheading:1354517-Blood Specimen Collection,
pubmed-meshheading:1354517-Cells, Cultured,
pubmed-meshheading:1354517-Colony-Forming Units Assay,
pubmed-meshheading:1354517-Feasibility Studies,
pubmed-meshheading:1354517-Fetal Blood,
pubmed-meshheading:1354517-Fetal Tissue Transplantation,
pubmed-meshheading:1354517-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:1354517-Hematopoietic Stem Cells,
pubmed-meshheading:1354517-Humans,
pubmed-meshheading:1354517-Infant, Newborn
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Human cord blood: a source of transplantable stem cells?
|
| pubmed:affiliation |
Kay Kendall Laboratory, Paterson Institute, Cancer Research Campaign, Manchester, UK.
|
| pubmed:publicationType |
Journal Article
|