| pubmed-article:1354275 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1354275 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:1354275 | lifeskim:mentions | umls-concept:C0031001 | lld:lifeskim |
| pubmed-article:1354275 | lifeskim:mentions | umls-concept:C1319315 | lld:lifeskim |
| pubmed-article:1354275 | lifeskim:mentions | umls-concept:C0085533 | lld:lifeskim |
| pubmed-article:1354275 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:1354275 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:1354275 | lifeskim:mentions | umls-concept:C1880198 | lld:lifeskim |
| pubmed-article:1354275 | pubmed:issue | 8818 | lld:pubmed |
| pubmed-article:1354275 | pubmed:dateCreated | 1992-9-17 | lld:pubmed |
| pubmed-article:1354275 | pubmed:abstractText | About half the patients treated with curative resection for colorectal cancer do not survive long-term. Adjuvant chemotherapy given during and after surgery may prevent hepatic metastases and improve patient survival. In patients with colorectal cancer, we have done a multicentre, randomised controlled trial comparing five-year survival after intraportal infusion of fluorouracil (1 g per day) plus heparin (10,000 U per day) (130 patients) or heparin alone (123) during curative resection and for 7 days thereafter, or after resection alone (145). There was no reduction in liver metastasis or increased overall survival advantage in either active-treatment arm of the study. However, patients who had stage III, Dukes' C (lymph-node-positive) tumours resected and were treated with fluorouracil plus heparin had a significant (p less than 0.03) survival advantage of about 16% compared with surgery-only controls. Further study of intraportal infusion of chemotherapeutic agent as adjuvant treatment to surgery in patients with colorectal cancer appears worthwhile. | lld:pubmed |
| pubmed-article:1354275 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1354275 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1354275 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1354275 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1354275 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1354275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1354275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1354275 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1354275 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1354275 | pubmed:issn | 0140-6736 | lld:pubmed |
| pubmed-article:1354275 | pubmed:author | pubmed-author:FieldingL PLP | lld:pubmed |
| pubmed-article:1354275 | pubmed:author | pubmed-author:HittingerRR | lld:pubmed |
| pubmed-article:1354275 | pubmed:author | pubmed-author:GraceR HRH | lld:pubmed |
| pubmed-article:1354275 | pubmed:author | pubmed-author:NEYL FLF | lld:pubmed |
| pubmed-article:1354275 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1354275 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:1354275 | pubmed:volume | 340 | lld:pubmed |
| pubmed-article:1354275 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1354275 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1354275 | pubmed:pagination | 502-6 | lld:pubmed |
| pubmed-article:1354275 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1354275 | pubmed:meshHeading | pubmed-meshheading:1354275-... | lld:pubmed |
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| pubmed-article:1354275 | pubmed:meshHeading | pubmed-meshheading:1354275-... | lld:pubmed |
| pubmed-article:1354275 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1354275 | pubmed:articleTitle | Randomised controlled trial of adjuvant chemotherapy by portal-vein perfusion after curative resection for colorectal adenocarcinoma. | lld:pubmed |
| pubmed-article:1354275 | pubmed:affiliation | Academic Surgical Unit, St Mary's Hospital, London, UK. | lld:pubmed |
| pubmed-article:1354275 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1354275 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:1354275 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:1354275 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:1354275 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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