| pubmed-article:1347675 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1347675 | lifeskim:mentions | umls-concept:C0055147 | lld:lifeskim |
| pubmed-article:1347675 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:1347675 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1347675 | pubmed:dateCreated | 1992-4-14 | lld:pubmed |
| pubmed-article:1347675 | pubmed:abstractText | Antihistamines are frequently employed in the treatment of allergic rhinitis and urticaria-angioedema syndrome. We analyzed the in vitro effects of cetirizine on the immune response. To this end the proliferation of peripheral mononuclear cells induced by mitogen and by -CD3, -CD2, or -CD28 monoclonal antibodies has been studied. Since the plasma peak of cetirizine following ingestion of 10 mg is about 1 microgram/mL, the drug was tested in the cultures at the concentration of 0.1, 1, or 10 micrograms/mL. No influence of cetirizine on T cell proliferation was detected. We also evaluated the effect of cetirizine on the expression of the following markers expressed by T cells upon activation: lymphocyte markers ICAM-1, HLA-DR, and CD25 surface expression, alpha-1-acid glycoprotein has been also studied. There was no effect of cetirizine on the investigated immunologic parameters; these data acquire clinical relevance when related to previous reports showing a depression of the immunologic response exerted by other compounds such as ketotifen and theophylline and when related to the recent data about the modulation of ICAM-1 expression on eosinophils by cetirizine. Cetirizine does not affect ICAM-1 expression of lymphocyte membrane. | lld:pubmed |
| pubmed-article:1347675 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1347675 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1347675 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1347675 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1347675 | pubmed:issn | 0003-4738 | lld:pubmed |
| pubmed-article:1347675 | pubmed:author | pubmed-author:PesceGG | lld:pubmed |
| pubmed-article:1347675 | pubmed:author | pubmed-author:CanonicaG WGW | lld:pubmed |
| pubmed-article:1347675 | pubmed:author | pubmed-author:CiprandiGG | lld:pubmed |
| pubmed-article:1347675 | pubmed:author | pubmed-author:RihouxJ PJP | lld:pubmed |
| pubmed-article:1347675 | pubmed:author | pubmed-author:RuffoniSS | lld:pubmed |
| pubmed-article:1347675 | pubmed:author | pubmed-author:BuscagliaSS | lld:pubmed |
| pubmed-article:1347675 | pubmed:author | pubmed-author:BoeroFF | lld:pubmed |
| pubmed-article:1347675 | pubmed:author | pubmed-author:JingGG | lld:pubmed |
| pubmed-article:1347675 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1347675 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:1347675 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1347675 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1347675 | pubmed:pagination | 251-4 | lld:pubmed |
| pubmed-article:1347675 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1347675 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1347675 | pubmed:articleTitle | Cetirizine does not influence the immune response. | lld:pubmed |
| pubmed-article:1347675 | pubmed:affiliation | Allergy and Clinical Immunology Service, Department of Internal Medicine Genoa, Italy. | lld:pubmed |
| pubmed-article:1347675 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1347675 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
