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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1992-4-14
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pubmed:abstractText |
Antihistamines are frequently employed in the treatment of allergic rhinitis and urticaria-angioedema syndrome. We analyzed the in vitro effects of cetirizine on the immune response. To this end the proliferation of peripheral mononuclear cells induced by mitogen and by -CD3, -CD2, or -CD28 monoclonal antibodies has been studied. Since the plasma peak of cetirizine following ingestion of 10 mg is about 1 microgram/mL, the drug was tested in the cultures at the concentration of 0.1, 1, or 10 micrograms/mL. No influence of cetirizine on T cell proliferation was detected. We also evaluated the effect of cetirizine on the expression of the following markers expressed by T cells upon activation: lymphocyte markers ICAM-1, HLA-DR, and CD25 surface expression, alpha-1-acid glycoprotein has been also studied. There was no effect of cetirizine on the investigated immunologic parameters; these data acquire clinical relevance when related to previous reports showing a depression of the immunologic response exerted by other compounds such as ketotifen and theophylline and when related to the recent data about the modulation of ICAM-1 expression on eosinophils by cetirizine. Cetirizine does not affect ICAM-1 expression of lymphocyte membrane.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Cetirizine,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H1 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyzine,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Ketotifen,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Orosomucoid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Theophylline
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0003-4738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1347675-Adult,
pubmed-meshheading:1347675-Antibodies, Monoclonal,
pubmed-meshheading:1347675-Antibody Formation,
pubmed-meshheading:1347675-Antigens, CD,
pubmed-meshheading:1347675-Antigens, CD28,
pubmed-meshheading:1347675-Antigens, CD3,
pubmed-meshheading:1347675-Antigens, CD4,
pubmed-meshheading:1347675-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1347675-Cell Adhesion Molecules,
pubmed-meshheading:1347675-Cell Division,
pubmed-meshheading:1347675-Cetirizine,
pubmed-meshheading:1347675-Dose-Response Relationship, Drug,
pubmed-meshheading:1347675-Female,
pubmed-meshheading:1347675-HLA-DR Antigens,
pubmed-meshheading:1347675-Histamine H1 Antagonists,
pubmed-meshheading:1347675-Histocompatibility Antigens Class II,
pubmed-meshheading:1347675-Humans,
pubmed-meshheading:1347675-Hydroxyzine,
pubmed-meshheading:1347675-Intercellular Adhesion Molecule-1,
pubmed-meshheading:1347675-Ketotifen,
pubmed-meshheading:1347675-Male,
pubmed-meshheading:1347675-Mitogens,
pubmed-meshheading:1347675-Orosomucoid,
pubmed-meshheading:1347675-Receptors, Antigen, T-Cell,
pubmed-meshheading:1347675-Receptors, Interleukin-2,
pubmed-meshheading:1347675-T-Lymphocytes,
pubmed-meshheading:1347675-Theophylline
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pubmed:year |
1992
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pubmed:articleTitle |
Cetirizine does not influence the immune response.
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pubmed:affiliation |
Allergy and Clinical Immunology Service, Department of Internal Medicine Genoa, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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