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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1992-12-30
|
| pubmed:abstractText |
With inside-out membrane vesicles derived from human red cells and incubated at pH > or = 6.6, an altered sodium pump stoichiometry (1Na+:2K+) associated with altered charge transfer is observed when the cytoplasmic Na+ concentration is reduced to very low levels (0.2 mM). With increased proton concentration (approximately pH 6.0), protons can substitute for Na+ or K+ ions such that the Na,K-ATPase can effect either electroneutral Na+/H+ exchange (K+ absent), H+/K+ exchange (Na+ absent), or H(+)-plus-Na+ cotransport in exchange for K+ (low Na+ concentration). Evidence that the stoichiometries of these exchanges are 3Na+/3H+, 2H+/2K+ and 1H(+)-plus-1Na+/2K+, respectively, is presented.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0302-2994
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
607
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
105-10
|
| pubmed:dateRevised |
2008-2-20
|
| pubmed:meshHeading | |
| pubmed:year |
1992
|
| pubmed:articleTitle |
Altered stoichiometry of the Na,K-ATPase.
|
| pubmed:affiliation |
Montreal General Hospital Research Institute, Quebec, Canada.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|