| pubmed-article:1331456 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1331456 | lifeskim:mentions | umls-concept:C0026818 | lld:lifeskim |
| pubmed-article:1331456 | lifeskim:mentions | umls-concept:C2936801 | lld:lifeskim |
| pubmed-article:1331456 | lifeskim:mentions | umls-concept:C0598405 | lld:lifeskim |
| pubmed-article:1331456 | lifeskim:mentions | umls-concept:C0076488 | lld:lifeskim |
| pubmed-article:1331456 | lifeskim:mentions | umls-concept:C1737964 | lld:lifeskim |
| pubmed-article:1331456 | lifeskim:mentions | umls-concept:C0233656 | lld:lifeskim |
| pubmed-article:1331456 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:1331456 | pubmed:dateCreated | 1992-12-1 | lld:pubmed |
| pubmed-article:1331456 | pubmed:abstractText | Ten analogs of muscimol and thiomuscimol in which the amino function was delocalized in an amidinic system were prepared by N2 alkylation of 6-aryl-3-aminopyridazines with (chloromethyl)isoxazole or (chloromethyl)isothiazole derivatives. These muscimol and thiomuscimol derivatives show potent binding properties for GABA-A receptors (they displace [3H]GABA and [3H]gabazine) and provoke convulsions after iv injections. They fit well with the model pharmacophore proposed by our group for the GABA-A antagonists and show similar structure-activity profiles to that of the pyridazinyl-GABAs. | lld:pubmed |
| pubmed-article:1331456 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1331456 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1331456 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1331456 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1331456 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1331456 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1331456 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1331456 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1331456 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1331456 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1331456 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1331456 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:1331456 | pubmed:author | pubmed-author:WermuthC GCG | lld:pubmed |
| pubmed-article:1331456 | pubmed:author | pubmed-author:ChambonJ PJP | lld:pubmed |
| pubmed-article:1331456 | pubmed:author | pubmed-author:SchlewerGG | lld:pubmed |
| pubmed-article:1331456 | pubmed:author | pubmed-author:MelikianAA | lld:pubmed |
| pubmed-article:1331456 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1331456 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:1331456 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:1331456 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1331456 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1331456 | pubmed:pagination | 4092-7 | lld:pubmed |
| pubmed-article:1331456 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:meshHeading | pubmed-meshheading:1331456-... | lld:pubmed |
| pubmed-article:1331456 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1331456 | pubmed:articleTitle | Condensation of muscimol or thiomuscimol with aminopyridazines yields GABA-A antagonists. | lld:pubmed |
| pubmed-article:1331456 | pubmed:affiliation | Centre de Neurochimie du CNRS, Strasbourg, France. | lld:pubmed |
| pubmed-article:1331456 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1331456 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:1331456 | lld:chembl |
