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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-11-13
|
| pubmed:abstractText |
The therapeutic effectiveness of a new combination therapy--pretreatment with transcatheter arterial embolization (TAE) and subsequent percutaneous ethanol injection (PEI)--for solitary large (> 3.0 cm in diameter) primary hepatocellular carcinoma lesions was compared with that of TAE alone. With TAE alone, a partial response of the tumor was seen in only 10% of the patients, and the 1-, 2-, and 3-year survival rates were calculated to be 68%, 37%, and 0%, respectively. Histologic examination of specimens obtained at hepatectomy showed that TAE alone caused complete necrosis in only 20% of the tumors. In contrast, PEI combined with TAE significantly (P < .05) increased the partial response rate (45%) and significantly (P < .01) prolonged the 1-, 2-, and 3-year survival rates (100%, 85%, and 85%, respectively). Combination therapy caused complete histologic necrosis in 83% of the tumors. It also was significantly (P < .05) better than TAE alone in terms of rate of primary tumor recurrence during follow-up.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0033-8419
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
185
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
457-60
|
| pubmed:dateRevised |
2006-4-13
|
| pubmed:meshHeading |
pubmed-meshheading:1329143-Aged,
pubmed-meshheading:1329143-Carcinoma, Hepatocellular,
pubmed-meshheading:1329143-Catheterization, Peripheral,
pubmed-meshheading:1329143-Cause of Death,
pubmed-meshheading:1329143-Chemoembolization, Therapeutic,
pubmed-meshheading:1329143-Combined Modality Therapy,
pubmed-meshheading:1329143-Doxorubicin,
pubmed-meshheading:1329143-Ethanol,
pubmed-meshheading:1329143-Female,
pubmed-meshheading:1329143-Follow-Up Studies,
pubmed-meshheading:1329143-Gelatin Sponge, Absorbable,
pubmed-meshheading:1329143-Hepatic Artery,
pubmed-meshheading:1329143-Humans,
pubmed-meshheading:1329143-Injections, Intralesional,
pubmed-meshheading:1329143-Iodized Oil,
pubmed-meshheading:1329143-Liver Neoplasms,
pubmed-meshheading:1329143-Male,
pubmed-meshheading:1329143-Middle Aged,
pubmed-meshheading:1329143-Neoplasm Recurrence, Local,
pubmed-meshheading:1329143-Remission Induction,
pubmed-meshheading:1329143-Survival Rate
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Hepatocellular carcinoma: treatment with percutaneous ethanol injection and transcatheter arterial embolization.
|
| pubmed:affiliation |
Third Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article
|