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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5054
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pubmed:dateCreated |
1992-5-20
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pubmed:abstractText |
The myoD family of DNA binding proteins has been implicated in the control of myogenesis in a variety of organisms. Searches for homologs in the nematode Caenorhabditis elegans yielded only one gene, designated hlh-1, expressed in body-wall muscle cells and their precursors. To assess the role of hlh-1 in C. elegans myogenesis, genetic deficiencies spanning the hlh-1 locus were isolated after gamma irradiation. Embryos homozygous for these deficiencies exhibited extensive body-wall muscle differentiation, including expression of several characteristic myofilament proteins and weak contracile behavior. Thus, zygotic hlh-1 expression was not required for body-wall muscle precursors to adopt muscle cell fates.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
256
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pubmed:geneSymbol |
MyoD,
hlh-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
240-3
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:1314423-Amino Acid Sequence,
pubmed-meshheading:1314423-Animals,
pubmed-meshheading:1314423-Base Sequence,
pubmed-meshheading:1314423-Caenorhabditis,
pubmed-meshheading:1314423-Cell Differentiation,
pubmed-meshheading:1314423-Chromosome Deletion,
pubmed-meshheading:1314423-Chromosome Mapping,
pubmed-meshheading:1314423-Crosses, Genetic,
pubmed-meshheading:1314423-DNA,
pubmed-meshheading:1314423-DNA-Binding Proteins,
pubmed-meshheading:1314423-Embryo, Nonmammalian,
pubmed-meshheading:1314423-Gamma Rays,
pubmed-meshheading:1314423-Homozygote,
pubmed-meshheading:1314423-Molecular Sequence Data,
pubmed-meshheading:1314423-Multigene Family,
pubmed-meshheading:1314423-Muscle Proteins,
pubmed-meshheading:1314423-Muscles,
pubmed-meshheading:1314423-MyoD Protein,
pubmed-meshheading:1314423-Oligodeoxyribonucleotides,
pubmed-meshheading:1314423-Polymerase Chain Reaction,
pubmed-meshheading:1314423-Sequence Homology, Nucleic Acid
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pubmed:year |
1992
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pubmed:articleTitle |
Body-wall muscle formation in Caenorhabditis elegans embryos that lack the MyoD homolog hlh-1.
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pubmed:affiliation |
Carnegie Institution of Washington, Baltimore, MD 21210.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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