Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-5-1
pubmed:abstractText
The effects of restraint stress (RS) and the opioid antagonist, naltrexone, were evaluated on humoral immune responsiveness and gastric mucosal integrity in rats. RS for 24 h, but not 6 h, attenuated both the primary (PAR) and secondary antibody response (SAR) to sheep red blood cells (SRBC) after a single exposure to the stressor. Naltrexone (1 or 5 mg/kg) dose-dependently aggravated the effects of RS on anti-SRBC antibody titre in both PAR and SAR studies. Further, in rats sensitized with SRBC, RS (24 h), in addition to lowering the humoral antibody response, also induced gastric mucosal lesions. Both these responses were further aggravated with naltrexone pretreatment. These results are discussed in light of interactions between immune and visceral responses, and their regulation by endogenous opioids, during RS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Modulation by naltrexone of stress-induced changes in humoral immune responsiveness and gastric mucosal integrity in rats.
pubmed:affiliation
Department of Pharmacology, University College of Medical Sciences, Shahdara, Delhi, India.
pubmed:publicationType
Journal Article