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rdf:type |
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lifeskim:mentions |
umls-concept:C0010853,
umls-concept:C0027950,
umls-concept:C0033268,
umls-concept:C0034793,
umls-concept:C0036536,
umls-concept:C0036537,
umls-concept:C0038836,
umls-concept:C0041904,
umls-concept:C0065739,
umls-concept:C0070794,
umls-concept:C0086418,
umls-concept:C0162493,
umls-concept:C0332307,
umls-concept:C0680829,
umls-concept:C1522492,
umls-concept:C1879547,
umls-concept:C1948023
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pubmed:dateCreated |
1992-4-16
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pubmed:abstractText |
In human neutrophils, mastoparan induced rapid F-actin polymerization which was followed by a slow and sustained depolymerization to below the initial F-actin content. Incubation of neutrophils with pertussis toxin inhibited mastoparan-stimulated actin polymerization; however it did not prevent sustained depolymerization of F-actin. Analyses of phospholipids performed in parallel revealed that mastoparan stimulated rapid formation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) and consumption of phosphatidylinositol 4,5-bisphosphate (PIP2). Pertussis toxin treatment blocked mastoparan-induced formation of PIP3. Furthermore, mastoparan stimulated the release of N-acetylglucosaminidase from primary granules. Cytochalasin B enhanced mastoparan-stimulated secretion. Mastoparan triggered superoxide radical production in a cytochalasin B-sensitive manner and induced complement type 3 receptor (CR3) up-regulation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-1697300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-1988505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2112547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2113529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2117607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2161855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2211588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2493246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2513319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2549071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2550825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2557829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2681192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2760463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2768336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2768337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2844854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-2846563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-3003581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-3027569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-3040735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-3098737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-3113327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-3543977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-540362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1312328-6643447
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylglucosaminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/N-Formylmethionine...,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pertussis Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors, Bordetella,
http://linkedlifedata.com/resource/pubmed/chemical/Wasp Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/mastoparan
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
282 ( Pt 2)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
393-7
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1312328-Acetylglucosaminidase,
pubmed-meshheading:1312328-Actins,
pubmed-meshheading:1312328-Flow Cytometry,
pubmed-meshheading:1312328-Free Radicals,
pubmed-meshheading:1312328-Humans,
pubmed-meshheading:1312328-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:1312328-Neutrophils,
pubmed-meshheading:1312328-Peptides,
pubmed-meshheading:1312328-Pertussis Toxin,
pubmed-meshheading:1312328-Phospholipids,
pubmed-meshheading:1312328-Superoxides,
pubmed-meshheading:1312328-Up-Regulation,
pubmed-meshheading:1312328-Virulence Factors, Bordetella,
pubmed-meshheading:1312328-Wasp Venoms
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pubmed:year |
1992
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pubmed:articleTitle |
Activation of human neutrophils by mastoparan. Reorganization of the cytoskeleton, formation of phosphatidylinositol 3,4,5-trisphosphate, secretion up-regulation of complement receptor type 3 and superoxide anion production are stimulated by mastoparan.
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pubmed:affiliation |
Rudolf-Bucheim-Institut für Pharmakologie, Justus-Liebig-Universität, Giessen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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