Source:http://linkedlifedata.com/resource/pubmed/id/12956759
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2003-9-5
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| pubmed:abstractText |
Bone marrow angiogenesis has recently been implicated in the pathophysiology and course of various haematological malignancies. Little is known, however, about the significance of this phenomenon in hairy cell leukaemia (HCL). We evaluated various morphometric characteristics of microvessels, highlighted by means of anti-CD34 immunohistochemistry, in the bone marrow of 44 patients with typical HCL, before and after treatment with interferon-alpha (IFN-alpha). Overall, bone marrow from 103 HCL patients and 20 controls was examined. Microvessel density (MVD) and several size- and shape-related parameters were quantified in the region of most intense vascularization using image analysis. MVD, size-related parameters and the percentage of branching microvessels were higher in HCL than in controls. Likewise, perimeter counts were higher in partial/non-responders than in complete responders. Achievement of complete response was accompanied by smaller calibre microvessels. IFN-alpha induced a decrease in MVD and branching values in cases with diffuse marrow involvement. In univariate analysis, progression-free survival was adversely affected by MVD, branching and major axis length. Multivariate analysis indicated that MVD/branching independently affected progression-free survival and the likelihood of complete response. Our data suggest that the generation of bone marrow microvessels indicated an increased risk of progression and IFN-alpha treatment failure in HCL. Furthermore, the prognostic significance of angiogenesis requires the concomitant assessment of MVD and the complexity of the microvascular network.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2b
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0007-1048
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| pubmed:author |
pubmed-author:AndroulakiAthinaA,
pubmed-author:AngelopoulouMaria KMK,
pubmed-author:GribabisDespina ADA,
pubmed-author:KavantzasNikolaosN,
pubmed-author:KittasChristosC,
pubmed-author:KokorisStyliani ISI,
pubmed-author:KorkolopoulouPenelopeP,
pubmed-author:KyrtsonisMaria CMC,
pubmed-author:PangalisGerassimos AGA,
pubmed-author:PatsourisEfstratiosE,
pubmed-author:SiakantarisMarina PMP,
pubmed-author:ThymaraIreneI
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| pubmed:issnType |
Print
|
| pubmed:volume |
122
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
900-10
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:12956759-Adult,
pubmed-meshheading:12956759-Aged,
pubmed-meshheading:12956759-Angiogenesis Inhibitors,
pubmed-meshheading:12956759-Antigens, CD34,
pubmed-meshheading:12956759-Antineoplastic Agents,
pubmed-meshheading:12956759-Bone Marrow,
pubmed-meshheading:12956759-Disease-Free Survival,
pubmed-meshheading:12956759-Female,
pubmed-meshheading:12956759-Follow-Up Studies,
pubmed-meshheading:12956759-Humans,
pubmed-meshheading:12956759-Interferon-alpha,
pubmed-meshheading:12956759-Leukemia, Hairy Cell,
pubmed-meshheading:12956759-Male,
pubmed-meshheading:12956759-Middle Aged,
pubmed-meshheading:12956759-Neovascularization, Pathologic,
pubmed-meshheading:12956759-Prognosis,
pubmed-meshheading:12956759-Proportional Hazards Models,
pubmed-meshheading:12956759-Recombinant Proteins,
pubmed-meshheading:12956759-Treatment Outcome
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| pubmed:year |
2003
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| pubmed:articleTitle |
A morphometric study of bone marrow angiogenesis in hairy cell leukaemia with clinicopathological correlations.
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| pubmed:affiliation |
Department of Pathology, First Department of Internal Medicine, School of Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece. pkorko@cc.uoa.gr
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| pubmed:publicationType |
Journal Article
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