Linked Life Data

12946691

Source:http://linkedlifedata.com/resource/pubmed/id/12946691

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-8-29
pubmed:abstractText
A growing body of research supports the view that choline is an essential nutrient during early development that has long-lasting effects on memory and attentional processes throughout the lifespan. This review describes the known effects of alterations in dietary choline availability both in adulthood and during early development. Although modest effects of choline on cognitive processes have been reported when choline is administered to adult animals, we have found that the perinatal period is a critical time for cholinergic organization of brain function. Choline supplementation during this period increases memory capacity and precision of the young adult and appears to prevent age-related memory and attentional decline. Deprivation of choline during early development leads to compromised cognitive function and increased decline with age. We propose that this organizational effect of choline availability may be due to relatively permanent alterations in the functioning of the cholinergic synapse, which we have called 'metabolic imprinting'.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0149-7634
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-99
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan.
pubmed:affiliation
Department of Psychological and Brain Sciences, Duke University, 9 Flowers Drive, Box 90086, Durham, NC 27708-0086, USA. meck@psych.duke.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review