rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
2003-8-22
|
pubmed:abstractText |
Administration of short-acting antihypertensive agents to patients with ischemic heart disease results in increased sympathetic nervous activity and is associated with worsened outcomes. Cilnidipine is an agent which blocks not only L-type calcium channels at the smooth muscle in the artery, but also N-type calcium channels at the presynaptic terminal. The goal of the present study was to determine the effect of cilnidipine on sympathetic nervous activity as on agent which blocks both L-type and N-type calcium channels at the presynaptic terminal, on sympathetic nervous activity in an experimental rat model using iodine-123 metaiodobenzylguanidine (MIBG) myocardial imaging.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0914-7187
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
321-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:12932117-3-Iodobenzylguanidine,
pubmed-meshheading:12932117-Animals,
pubmed-meshheading:12932117-Antihypertensive Agents,
pubmed-meshheading:12932117-Blood Pressure,
pubmed-meshheading:12932117-Calcium Channel Blockers,
pubmed-meshheading:12932117-Dihydropyridines,
pubmed-meshheading:12932117-Heart,
pubmed-meshheading:12932117-Heart Conduction System,
pubmed-meshheading:12932117-Heart Rate,
pubmed-meshheading:12932117-Male,
pubmed-meshheading:12932117-Nifedipine,
pubmed-meshheading:12932117-Radiopharmaceuticals,
pubmed-meshheading:12932117-Rats,
pubmed-meshheading:12932117-Rats, Wistar,
pubmed-meshheading:12932117-Sympathetic Nervous System
|
pubmed:year |
2003
|
pubmed:articleTitle |
Cilnidipine as an agent to lower blood pressure without sympathetic nervous activation as demonstrated by iodine-123 metaiodobenzylguanidine imaging in rat hearts.
|
pubmed:affiliation |
Department of Internal Medicine, Cardiovascular Division, Hyogo College of Medicine, Nishinomiya, Japan. takatosi@hyo-med.ac.jp
|
pubmed:publicationType |
Journal Article,
Comparative Study
|