Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2003-8-8
pubmed:abstractText
Bacteroides, a predominant commensal bacteria in the gut, are thought to be responsible for the development of inflammatory bowel disease (IBD). In the present study, we examined whether or not bifidobacteria suppress B. vulgatus, a representative pathogenic Bacteroides species, in both the coculture system and the gnotobiotic murine model. As a result, Bifidobacterium infantis 1222 highly inhibited the growth of B. vulgatus in the coculture and also significantly suppressed the systemic antibody response raised by B. vulgatus colonizing the gut in gnotobiotic mice. Colonization of the mice by B. vulgatus increased the number of Peyer's patch (PP) cells bearing PNA (peanut agglutinin)+/anti-kappa+ phenotype, which represents plasma cell-like B cells. Moreover, treatment of those B. vulgatus-implanted mice with B. infantis 1222 abrogated such increase in the number of PNA+/anti-kappa+ cells. These results thus suggested that B. infantis 1222 protected the gut epithelial layer including the PP from being invaded by Bacteroides, thereby suppressing the systemic antibody response raised by Bacteroides.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0385-5600
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
371-8
pubmed:dateRevised
2006-4-13
pubmed:meshHeading
pubmed-meshheading:12906096-Administration, Rectal, pubmed-meshheading:12906096-Animals, pubmed-meshheading:12906096-Antibodies, Bacterial, pubmed-meshheading:12906096-Bacteroides, pubmed-meshheading:12906096-Bacteroides Infections, pubmed-meshheading:12906096-Bifidobacterium, pubmed-meshheading:12906096-Coculture Techniques, pubmed-meshheading:12906096-Colitis, pubmed-meshheading:12906096-Disease Models, Animal, pubmed-meshheading:12906096-Germ-Free Life, pubmed-meshheading:12906096-Haptens, pubmed-meshheading:12906096-Immunoglobulin G, pubmed-meshheading:12906096-Immunoglobulin kappa-Chains, pubmed-meshheading:12906096-Inflammatory Bowel Diseases, pubmed-meshheading:12906096-Mice, pubmed-meshheading:12906096-Mice, Inbred BALB C, pubmed-meshheading:12906096-Peanut Agglutinin, pubmed-meshheading:12906096-Peyer's Patches, pubmed-meshheading:12906096-Probiotics, pubmed-meshheading:12906096-Receptors, Mitogen, pubmed-meshheading:12906096-Species Specificity, pubmed-meshheading:12906096-Trinitrobenzenesulfonic Acid
pubmed:year
2003
pubmed:articleTitle
The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease.
pubmed:affiliation
Departments of Infectious Diseases, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
pubmed:publicationType
Journal Article, Evaluation Studies