Linked Life Data

12882925

Source:http://linkedlifedata.com/resource/pubmed/id/12882925

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2003-7-28
pubmed:abstractText
IGFs and their binding proteins (IGFBPs) play a significant role in metabolic regulation, and there is growing evidence that they also exert important vascular effects. IGFBP-1 contributes to glucose counterregulation, and observational studies demonstrate an inverse association between circulating IGFBP-1 levels and cardiovascular risk factors. Furthermore, IGFBP-1 levels are lower in subjects with overt macrovascular disease. We therefore hypothesized that IGFBP-1 exerts potentially beneficial effects, either directly or indirectly, on blood pressure regulation and vascular function. We tested this hypothesis using a unique transgenic mouse, which overexpresses human IGFBP-1, and explored the effect of this protein on metabolic, blood pressure, and vascular homeostasis. IGFBP-1-overexpressing mice exhibited postprandial hyperinsulinemia with preservation of glucocompetence and insulin sensitivity. Blood pressure was unchanged in the fasting state but was significantly lower in transgenic mice after a carbohydrate load. Aortic rings from IGFBP-1-overexpressing mice were hypocontractile in response to vasoconstrictors, and relaxation responses were unimpaired. Basal nitric oxide production was increased and endothelial nitric oxide synthase mRNA expression upregulated in aortae of these mice. Our data suggest that IGFBP-1 plays an important and potentially beneficial role in regulating metabolic and vascular homeostasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2075-82
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:12882925-Animals, pubmed-meshheading:12882925-Aorta, pubmed-meshheading:12882925-Blood Pressure, pubmed-meshheading:12882925-Cardiovascular Diseases, pubmed-meshheading:12882925-Endothelium, Vascular, pubmed-meshheading:12882925-Gene Expression, pubmed-meshheading:12882925-Homeostasis, pubmed-meshheading:12882925-Insulin, pubmed-meshheading:12882925-Insulin-Like Growth Factor Binding Protein 1, pubmed-meshheading:12882925-Insulin-Like Growth Factor I, pubmed-meshheading:12882925-Lipids, pubmed-meshheading:12882925-Male, pubmed-meshheading:12882925-Mice, pubmed-meshheading:12882925-Mice, Inbred CBA, pubmed-meshheading:12882925-Mice, Transgenic, pubmed-meshheading:12882925-Nitric Oxide Synthase, pubmed-meshheading:12882925-Nitric Oxide Synthase Type II, pubmed-meshheading:12882925-Nitric Oxide Synthase Type III, pubmed-meshheading:12882925-Risk Factors, pubmed-meshheading:12882925-Vasoconstriction
pubmed:year
2003
pubmed:articleTitle
Vascular endothelial function and blood pressure homeostasis in mice overexpressing IGF binding protein-1.
pubmed:affiliation
Department of Cardiology, Guy's, King's and St. Thomas' School of Medicine, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't