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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2 Pt 1
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pubmed:dateCreated |
2003-7-10
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pubmed:abstractText |
The growth suppressive genes p16INK4a and p14ARF located on the 9p21 gene cluster have active roles in the Rb and p53 growth control pathways, respectively. p16INK4a is a cyclin dependent kinase inhibitor functioning upstream of Rb. p14ARF restrains cell growth by abrogating Mdm2 inhibition of p53 activity, thereby, facilitating p53 mediated cell cycle arrest and apoptosis. To elucidate specific targets and aberrations affecting the 9p21 chromosomal region in bladder cancer tumorigenesis alterations in the p16INK4a and p14ARF genes were analyzed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-5347
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
595-600
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12853838-Blotting, Southern,
pubmed-meshheading:12853838-Carcinoma, Transitional Cell,
pubmed-meshheading:12853838-DNA Methylation,
pubmed-meshheading:12853838-DNA Mutational Analysis,
pubmed-meshheading:12853838-Gene Deletion,
pubmed-meshheading:12853838-Genes, Retinoblastoma,
pubmed-meshheading:12853838-Genes, p16,
pubmed-meshheading:12853838-Genes, p53,
pubmed-meshheading:12853838-Humans,
pubmed-meshheading:12853838-Mutation,
pubmed-meshheading:12853838-Polymerase Chain Reaction,
pubmed-meshheading:12853838-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:12853838-RNA, Messenger,
pubmed-meshheading:12853838-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12853838-Urinary Bladder Neoplasms
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pubmed:year |
2003
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pubmed:articleTitle |
Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer.
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pubmed:affiliation |
Department of Microbiology, Kaoshiung Medical University, Taiwan.
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pubmed:publicationType |
Journal Article
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