Linked Life Data

12839514

Source:http://linkedlifedata.com/resource/pubmed/id/12839514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-7-3
pubmed:abstractText
Schizophrenia is associated with cortical asymmetries concentrated in the left fronto-temporal hemisphere. In order to look for functional asymmetries between the two hemispheres, the stimulus-response times of patients were split into smaller periods and the interhemispheric and intrahemispheric correlations between these periods were investigated. Three groups were compared to each other: 22 patients with schizophrenia (Diagnostic and Statistical Manual of Mental Disorders, 4th edn; DSM-IV) treated with neuroleptics; 24 psychiatric neuroleptic-treated patients without schizophrenia; and 30 healthy subjects. All subjects were investigated by simple (one stimulus-one response) and complex (two stimuli-two responses), auditory and visual, right-hemispheric and left-hemispheric stimulus-response tasks. There were no intrahemispheric but significant interhemispheric correlations between the two auditory and between the two visual time fragments in both the healthy and the neuroleptic control group. In contrast there was a significant intrahemispheric correlation between the auditory and visual time fragment in the left hemisphere of patients with schizophrenia and no interhemispheric correlation between the auditory times. The reduction of the interhemispheric auditory correlation is interpreted as an auditory disintegration, the appearance of the left-hemispheric audiovisual correlation as an audiovisual 'hyperintegration' in patients with schizophrenia. It is questionable as to whether these findings are due to schizophrenia or to the neuroleptic treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1323-1316
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
353-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Symmetry reversal in schizophrenia.
pubmed:affiliation
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany. Roalnd.Kalb@psych.med.uni-erlangen.de
pubmed:publicationType
Journal Article, Clinical Trial, Case Reports